Furethidine

Furethidine
Clinical data
Other names	ethyl 4-phenyl-1-(2-tetrahydrofurfuryloxyethyl)piperidine-4-carboxylate
ATC code	none;
Legal status
Legal status	AU: S9 (Prohibited substance); BR: Class A1 (Narcotic drugs); CA: Schedule I; DE: Anlage I (Authorized scientific use only); UK: Class A; US: Schedule I;
Identifiers
	IUPAC name ethyl 1-[2-(oxolan-2-ylmethoxy)ethyl]-4-phenylpiperidine-4-carboxylate;
CAS Number	2385-81-1;
PubChem CID	61306;
DrugBank	DB01464 ;
ChemSpider	55245 ;
UNII	6U9XA4JOD4;
KEGG	D12682 ;
ChEMBL	ChEMBL2105078;
ECHA InfoCard	100.017.451
Chemical and physical data
Formula	C21H31NO4
Molar mass	361.482 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC)C3(c1ccccc1)CCN(CCOCC2OCCC2)CC3;
	InChI InChI=1S/C21H31NO4/c1-2-25-20(23)21(18-7-4-3-5-8-18)10-12-22(13-11-21)14-16-24-17-19-9-6-15-26-19/h3-5,7-8,19H,2,6,9-17H2,1H3 ; Key:NNCOZXNZFLUYGG-UHFFFAOYSA-N ;
	(verify)

Furethidine is a 4-phenyl piperidine derivative that is related to the clinically used opioid analgesic drug pethidine (meperidine), but with around 25x higher potency. According to another source, Furethidine is 500/30 = 16.7 x the potency of pethidine (table VII).

Furethidine is not currently used in medicine and is a Class A/Schedule I drug which is controlled under UN drug conventions. It has similar effects to other opioid derivatives, such as analgesia, sedation, nausea and respiratory depression. In the United States it is a Schedule I Narcotic controlled substance with the ACSCN of 9626.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.