GLUT5

SLC2A5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4YB9, 4YBQ
Identifiers
Aliases	SLC2A5, GLUT-5, GLUT5, solute carrier family 2 member 5
External IDs	OMIM: 138230 MGI: 1928369 HomoloGene: 74459 GeneCards: SLC2A5
Gene location (Human)
Chr.	Chromosome 1 (human)
End	9,088,478 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	150,228,626 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; biceps brachii; ; vastus lateralis muscle; ; triceps brachii muscle; ; bone marrow; ; bone marrow cells; ; gastrocnemius muscle; ; kidney tubule; ; deltoid muscle;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; islet of Langerhans; ; duodenum; ; proximal tubule; ; parotid gland; ; kidney; ; jejunum; ; submandibular gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	transmembrane transporter activity; transporter activity; fructose binding; fructose transmembrane transporter activity; glucose transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; apical plasma membrane; sarcolemma; extracellular exosome; specific granule membrane;
Biological process	cellular response to fructose stimulus; fructose transmembrane transport; carbohydrate transport; fructose import across plasma membrane; response to fructose; transmembrane transport; glucose transmembrane transport; regulation of systemic arterial blood pressure mediated by a chemical signal; neutrophil degranulation; intestinal hexose absorption; transport; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	6518
	56485
	ENSG00000142583
	ENSMUSG00000028976
	P22732
	Q9WV38
	NM_001135585; NM_003039; NM_001328619; NM_001328620; NM_001328621
	NM_019741
	NP_001129057; NP_001315548; NP_001315549; NP_001315550; NP_003030
	NP_062715
	Wikidata
View/Edit Human	View/Edit Mouse

GLUT5 is a fructose transporter expressed on the apical border of enterocytes in the small intestine. GLUT5 allows for fructose to be transported from the intestinal lumen into the enterocyte by facilitated diffusion due to fructose's high concentration in the intestinal lumen. GLUT5 is also expressed in skeletal muscle, testis, kidney, fat tissue (adipocytes), and brain.

Fructose malabsorption or Dietary Fructose Intolerance is a dietary disability of the small intestine, where the amount of fructose carrier in enterocytes is deficient.

In humans the GLUT5 protein is encoded by the SLC2A5 gene.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.