Fructose-bisphosphate aldolase
Fructose-bisphosphate aldolase (EC 4.1.2.13), often just aldolase, is an enzyme catalyzing a reversible reaction that splits the aldol, fructose 1,6-bisphosphate, into the triose phosphates dihydroxyacetone phosphate (DHAP) and glyceraldehyde 3-phosphate (G3P). Aldolase can also produce DHAP from other (3S,4R)-ketose 1-phosphates such as fructose 1-phosphate and sedoheptulose 1,7-bisphosphate. Gluconeogenesis and the Calvin cycle, which are anabolic pathways, use the reverse reaction. Glycolysis, a catabolic pathway, uses the forward reaction. Aldolase is divided into two classes by mechanism.
| Fructose-bisphosphate aldolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Fructose-bisphosphate aldolase octamer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 4.1.2.13 | ||||||||
| CAS no. | 9024-52-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| Fructose-bisphosphate aldolase class-I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
fructose 1,6-bisphosphate aldolase from rabbit liver | |||||||||
| Identifiers | |||||||||
| Symbol | Glycolytic | ||||||||
| Pfam | PF00274 | ||||||||
| InterPro | IPR000741 | ||||||||
| PROSITE | PDOC00143 | ||||||||
| SCOP2 | 1ald / SCOPe / SUPFAM | ||||||||
| CDD | cd00344 | ||||||||
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| Fructose-bisphosphate aldolase class-II | |||||||||
|---|---|---|---|---|---|---|---|---|---|
class II fructose-1,6-bisphosphate aldolase in complex with phosphoglycolohydroxamate | |||||||||
| Identifiers | |||||||||
| Symbol | F_bP_aldolase | ||||||||
| Pfam | PF01116 | ||||||||
| Pfam clan | CL0036 | ||||||||
| InterPro | IPR000771 | ||||||||
| PROSITE | PDOC00523 | ||||||||
| SCOP2 | 1dos / SCOPe / SUPFAM | ||||||||
| CDD | cd00453 | ||||||||
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The word aldolase also refers, more generally, to an enzyme that performs an aldol reaction (creating an aldol) or its reverse (cleaving an aldol), such as Sialic acid aldolase, which forms sialic acid. See the list of aldolases.