Formins
Formins (formin homology proteins) are a group of proteins that are involved in the polymerization of actin and associate with the fast-growing end (barbed end) of actin filaments. Most formins are Rho-GTPase effector proteins. Formins regulate the actin and microtubule cytoskeleton and are involved in various cellular functions such as cell polarity, cytokinesis, cell migration and SRF transcriptional activity. Formins are multidomain proteins that interact with diverse signalling molecules and cytoskeletal proteins, although some formins have been assigned functions within the nucleus.
| formin 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | FMN1 | ||||||
| Alt. symbols | LD, FMN | ||||||
| NCBI gene | 342184 | ||||||
| HGNC | 3768 | ||||||
| OMIM | 136535 | ||||||
| RefSeq | NM_001103184 | ||||||
| UniProt | Q68DA7 | ||||||
| Other data | |||||||
| Locus | Chr. 15 q13-q14 | ||||||
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| Formin Homology Region 1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Drf_FH1 | ||||||||
| Pfam | PF06346 | ||||||||
| InterPro | IPR009408 | ||||||||
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| Formin Homology 2 Domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
crystal structures of a formin homology-2 domain reveal a tethered-dimer architecture | |||||||||
| Identifiers | |||||||||
| Symbol | FH2 | ||||||||
| Pfam | PF02181 | ||||||||
| InterPro | IPR015425 | ||||||||
| SMART | FH2 | ||||||||
| SCOP2 | 1ux5 / SCOPe / SUPFAM | ||||||||
| |||||||||
| Diaphanous FH3 Domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
crystal structure of mdia1 gbd-fh3 in complex with rhoc-gmppnp | |||||||||
| Identifiers | |||||||||
| Symbol | Drf_FH3 | ||||||||
| Pfam | PF06367 | ||||||||
| Pfam clan | CL0020 | ||||||||
| InterPro | IPR010472 | ||||||||
| |||||||||
| DRF Autoregulatory Domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
crystal structure of the n-terminal mdia1 armadillo repeat region and dimerisation domain in complex with the mdia1 autoregulatory domain (dad) | |||||||||
| Identifiers | |||||||||
| Symbol | Drf_DAD | ||||||||
| Pfam | PF06345 | ||||||||
| InterPro | IPR010465 | ||||||||
| |||||||||
| Diaphanous GTPase-binding Domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
crystal structure of mdia1 gbd-fh3 in complex with rhoc-gmppnp | |||||||||
| Identifiers | |||||||||
| Symbol | Drf_GBD | ||||||||
| Pfam | PF06371 | ||||||||
| Pfam clan | CL0020 | ||||||||
| InterPro | IPR010473 | ||||||||
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