Fluvastatin

Fluvastatin
Clinical data
Trade names	Lescol, others
AHFS/Drugs.com	Monograph
MedlinePlus	a694010
Pregnancy; category	AU: D;
Routes of; administration	By mouth (capsules, tablets)
ATC code	C10AA04 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	24–30%
Protein binding	>98%
Metabolism	Hepatic: CYP2C9 (75%), CYP3A4 (20%), CYP2C8 (5%)
Elimination half-life	1–3 hours (capsule), 9 hours (XR formulations)
Excretion	Faeces (95%), urine (5%)
Identifiers
	IUPAC name (3R,5S,6E)-7-[3-(4-Fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid;
CAS Number	93957-54-1 ;
PubChem CID	446155;
IUPHAR/BPS	2951;
DrugBank	DB01095 ;
ChemSpider	393587 ;
UNII	4L066368AS;
KEGG	D07983 ;
ChEBI	CHEBI:38565 ;
ChEMBL	ChEMBL1078 ;
CompTox Dashboard (EPA)	DTXSID2020636 ;
ECHA InfoCard	100.224.327
Chemical and physical data
Formula	C24H26FNO4
Molar mass	411.473 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)C[C@H](O)C[C@H](O)/C=C/c2c(c1ccccc1n2C(C)C)c3ccc(F)cc3;
	InChI InChI=1S/C24H26FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30)/b12-11+/t18-,19-/m1/s1 ; Key:FJLGEFLZQAZZCD-MCBHFWOFSA-N ;
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Fluvastatin is a member of the statin drug class, used to treat hypercholesterolemia and to prevent cardiovascular disease.

It was patented in 1982 and approved for medical use in 1994. It is on the World Health Organization's List of Essential Medicines.

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