Fispemifene

Fispemifene
Clinical data
Other names	HM-101
Identifiers
	IUPAC name 2-(2-(4-((1Z)-4-Chloro-1,2-diphenylbut-1-enyl)phenoxy)ethoxy)ethanol;
CAS Number	341524-89-8;
PubChem CID	9954033;
ChemSpider	8129643;
UNII	3VZ2833V08;
KEGG	D10008;
ChEMBL	ChEMBL2107341;
Chemical and physical data
Formula	C26H27ClO3
Molar mass	422.95 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC=C(C=C1)/C(=C(/C2=CC=CC=C2)\C3=CC=C(C=C3)OCCOCCO)/CCCl;
	InChI InChI=1S/C26H27ClO3/c27-16-15-25(21-7-3-1-4-8-21)26(22-9-5-2-6-10-22)23-11-13-24(14-12-23)30-20-19-29-18-17-28/h1-14,28H,15-20H2/b26-25-; Key:NKZTZAQIKKGTDB-QPLCGJKRSA-N;

Fispemifene (INN, USAN) (developmental code name HM-101) is a nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group that was developed for the treatment of male hypogonadism but was abandoned and never marketed. It reached phase II clinical trials for this indication before development was terminated in March 2016. The drug failed to achieve statistical significance on key effectiveness endpoints in clinical trials and was discontinued by its developer for strategic reasons.

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