Fischer indole synthesis
The Fischer indole synthesis is a chemical reaction that produces the aromatic heterocycle indole from a (substituted) phenylhydrazine and an aldehyde or ketone under acidic conditions. The reaction was discovered in 1883 by Emil Fischer. Today antimigraine drugs of the triptan class are often synthesized by this method.
| Fischer indole synthesis | |
|---|---|
| Named after | Hermann Emil Fischer |
| Reaction type | Ring forming reaction |
| Identifiers | |
| Organic Chemistry Portal | fischer-indole-synthesis |
| RSC ontology ID | RXNO:0000064 |
This reaction can be catalyzed by Brønsted acids such as HCl, H2SO4, polyphosphoric acid and p-toluenesulfonic acid or Lewis acids such as boron trifluoride, zinc chloride, and aluminium chloride.
Several reviews have been published.
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