Fibrillin
Fibrillin is a glycoprotein, which is essential for the formation of elastic fibers found in connective tissue. Fibrillin is secreted into the extracellular matrix by fibroblasts and becomes incorporated into the insoluble microfibrils, which appear to provide a scaffold for deposition of elastin.
| fibrillin 1 | |||||||
|---|---|---|---|---|---|---|---|
Crystallographic structure of the cbEGF9-hybrid2-cbEGF10 region of human fibrillin 1. | |||||||
| Identifiers | |||||||
| Symbol | FBN1 | ||||||
| Alt. symbols | FBN, MFS1, WMS | ||||||
| NCBI gene | 2200 | ||||||
| HGNC | 3603 | ||||||
| OMIM | 134797 | ||||||
| PDB | 2W86 | ||||||
| RefSeq | NM_000138 | ||||||
| UniProt | P35555 | ||||||
| Other data | |||||||
| Locus | Chr. 15 q21.1 | ||||||
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| fibrillin 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | FBN2 | ||||||
| Alt. symbols | CCA | ||||||
| NCBI gene | 2201 | ||||||
| HGNC | 3604 | ||||||
| OMIM | 121050 | ||||||
| RefSeq | NM_001999 | ||||||
| UniProt | P35556 | ||||||
| Other data | |||||||
| Locus | Chr. 5 q23-q31 | ||||||
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| fibrillin 3 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | FBN3 | ||||||
| NCBI gene | 84467 | ||||||
| HGNC | 18794 | ||||||
| OMIM | 608529 | ||||||
| RefSeq | NM_032447 | ||||||
| UniProt | Q75N90 | ||||||
| Other data | |||||||
| Locus | Chr. 19 p13 | ||||||
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