Tyrosine-protein kinase Fes/Fps

FES
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WQU, 2DCR, 3BKB, 3CBL, 3CD3, 4DYL, 4E93
Identifiers
Aliases	FES, FPS, Feline sarcoma oncogene, FES proto-oncogene, tyrosine kinase
External IDs	OMIM: 190030 MGI: 95514 HomoloGene: 37563 GeneCards: FES
Gene location (Human)
Chr.	Chromosome 15 (human)
End	90,895,776 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	80,037,694 bp
RNA expression pattern
	Top expressed in
	monocyte; ; spleen; ; right lung; ; upper lobe of left lung; ; blood; ; sural nerve; ; right lobe of liver; ; left uterine tube; ; gallbladder; ; right lobe of thyroid gland;
	Top expressed in
	bone marrow; ; ankle joint; ; blood; ; spleen; ; internal carotid artery; ; body of femur; ; external carotid artery; ; right lung; ; calvaria; ; right lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; microtubule binding; immunoglobulin receptor binding; non-membrane spanning protein tyrosine kinase activity; kinase activity; protein binding; phosphatidylinositol binding; ATP binding; lipid binding; protein tyrosine kinase activity;
Cellular component	cytoplasm; cytosol; Golgi apparatus; membrane; focal adhesion; microtubule cytoskeleton; extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; cell junction; cytoskeleton; cytoplasmic vesicle;
Biological process	phosphorylation; regulation of vesicle-mediated transport; regulation of cell motility; multicellular organism development; chemotaxis; protein phosphorylation; regulation of cell adhesion; regulation of cell population proliferation; microtubule bundle formation; regulation of cell shape; positive regulation of neuron projection development; positive regulation of microtubule polymerization; peptidyl-tyrosine autophosphorylation; regulation of cell differentiation; protein autophosphorylation; peptidyl-tyrosine phosphorylation; regulation of mast cell degranulation; cell population proliferation; innate immune response; positive regulation of actin cytoskeleton reorganization; positive regulation of myeloid cell differentiation; epidermal growth factor receptor signaling pathway; cell migration; centrosome cycle; cell adhesion; positive regulation of monocyte differentiation; cellular response to vitamin D;
	Sources:Amigo / QuickGO
Orthologs
	2242
	14159
	ENSG00000182511
	ENSMUSG00000053158
	P07332
	P16879
	NM_001143783; NM_001143784; NM_001143785; NM_002005
	NM_010194
	NP_001137255; NP_001137256; NP_001137257; NP_001996
	NP_034324
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein kinase Fes/Fps also known as proto-oncogene c-Fes/Fps is an enzyme that in humans is encoded by the FES gene. FES was originally cloned as a retroviral oncogene from feline (v-FES) and avian (v-FPS) sarcomas. This triggered the subsequent identification and cloning of the cellular FES (c-FES) genes (also referred to as FPS) in birds and mammals.

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