Dimethylallyltranstransferase

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Dimethylallyltranstransferase
Dimethylallyltranstransferase
Identifiers
EC no.	2.5.1.1
CAS no.	9032-79-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
PMC
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PMC	articles
PubMed	articles
NCBI	proteins

FDPS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YQ7, 1YV5, 1ZW5, 2F7M, 2F89, 2F8C, 2F8Z, 2F92, 2F94, 2F9K, 2OPM, 2OPN, 2QIS, 2RAH, 2VF6, 3B7L, 3CP6, 3N1V, 3N1W, 3N3L, 3N45, 3N46, 3N49, 3N5H, 3N5J, 3N6K, 3RYE, 3S4J, 4DEM, 4GA3, 4H5C, 4H5D, 4H5E, 4JVJ, 4KFA, 4KPD, 4KPJ, 4KQ5, 4KQS, 4KQU, 4L2X, 4LFV, 4LPG, 4LPH, 4N1Z, 4N9U, 4NFI, 4NFJ, 4NFK, 4NG6, 4NKE, 4NKF, 4NUA, 4OGU, 4P0V, 4P0W, 4P0X, 4PVX, 4PVY, 4Q23, 4QPF, 4QXS, 4RXA, 4XQR, 5CG5, 5DIQ, 5CG6, 5DJR, 5DJP, 4XQS, 5DJV, 5DGN, 4XQT, 5DGM, 5DGS
Identifiers
Aliases	FDPS, FPPS, FPS, POROK9, farnesyl diphosphate synthase
External IDs	OMIM: 134629 MGI: 104888 HomoloGene: 1519 GeneCards: FDPS
EC number	2.5.1.1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	155,320,666 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	89,009,266 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; right adrenal gland; ; right lobe of liver; ; upper lobe of left lung; ; vulva; ; left adrenal gland; ; right lung; ; islet of Langerhans; ; skin of abdomen; ; rectum;
	Top expressed in
	mesencephalon; ; neural tube; ; morula; ; lip; ; esophagus; ; hepatobiliary system; ; exocrine gland; ; liver; ; ovary; ; adrenal gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; metal ion binding; geranyltranstransferase activity; dimethylallyltranstransferase activity; RNA binding;
Cellular component	nucleoplasm; cytoplasm; cytosol; mitochondrion;
Biological process	cholesterol biosynthetic process; steroid metabolic process; viral process; cholesterol metabolic process; geranyl diphosphate biosynthetic process; sterol biosynthetic process; isoprenoid biosynthetic process; lipid metabolism; steroid biosynthetic process; farnesyl diphosphate biosynthetic process; regulation of cholesterol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	2224
	110196
	ENSG00000160752
	ENSMUSG00000059743
	P14324
	Q920E5
NM_001135821; NM_001135822; NM_001242824; NM_001242825; NM_002004;
	NM_001378424; NM_001378425
	NM_001253751; NM_134469; NM_180985
NP_001129293; NP_001129294; NP_001229753; NP_001229754; NP_001995;
	NP_001365353; NP_001365354
	NP_001240680; NP_608219
	Wikidata
View/Edit Human	View/Edit Mouse

Dimethylallyltranstransferase (DMATT), also known as farnesylpyrophosphate synthase (FPPS) or as farnesyldiphosphate synthase (FDPS), is an enzyme that in humans is encoded by the FDPS gene and catalyzes the transformation of dimethylallylpyrophosphate (DMAPP) and isopentenyl pyrophosphate (IPP) into farnesylpyrophosphate (FPP).

Farnesyldiphosphate synthase (farnesylpyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)

Identifiers

Symbol

FDPS

Other data

Chr. 1 q22

Search for
Structures	Swiss-model
Domains	InterPro

Pyrophosphate is also involved, as both a reactant and a product. Geranylpyrophosphate is created in an intermediate step.

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