Farnesoid X receptor

NR1H4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1OSH, 3BEJ, 3DCT, 3DCU, 3FLI, 3FXV, 3GD2, 3HC5, 3HC6, 3L1B, 3OKH, 3OKI, 3OLF, 3OMK, 3OMM, 3OOF, 3OOK, 3RUT, 3RUU, 3RVF, 3P88, 3P89, 4OIV, 4WVD, 4QE6, 4QE8
Identifiers
Aliases	NR1H4, BAR, FXR, HRR-1, HRR1, RIP14, nuclear receptor subfamily 1 group H member 4, PFIC5
External IDs	OMIM: 603826 MGI: 1352464 HomoloGene: 3760 GeneCards: NR1H4
Gene location (Human)
Chr.	Chromosome 12 (human)
End	100,564,414 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	89,369,447 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right adrenal gland; ; oocyte; ; left adrenal gland; ; jejunal mucosa; ; duodenum; ; secondary oocyte; ; kidney; ; kidney tubule; ; gallbladder;
	Top expressed in
	ileum; ; left lobe of liver; ; kidney; ; proximal tubule; ; Paneth cell; ; jejunum; ; duodenum; ; left colon; ; crypt of lieberkuhn of small intestine; ; proximal straight tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; DNA binding; transcription corepressor activity; DNA-binding transcription factor activity; transcription coactivator activity; zinc ion binding; DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding; retinoid X receptor binding; steroid hormone receptor activity; bile acid binding; protein binding; nuclear receptor binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; chenodeoxycholic acid binding; transcription cis-regulatory region binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; nuclear receptor activity; bile acid receptor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription factor binding; nuclear receptor coactivator activity; signaling receptor activity;
Cellular component	nucleoplasm; nucleus; RNA polymerase II transcription regulator complex;
Biological process	Notch signaling pathway; cellular triglyceride homeostasis; cellular response to organonitrogen compound; regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of ammonia assimilation cycle; toll-like receptor 4 signaling pathway; immune system process; histone H3-R17 methylation; regulation of transcription by RNA polymerase II; positive regulation of glutamate metabolic process; intracellular bile acid receptor signaling pathway; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; regulation of low-density lipoprotein particle clearance; regulation of bile acid biosynthetic process; regulation of cholesterol metabolic process; regulation of urea metabolic process; intracellular receptor signaling pathway; negative regulation of bile acid biosynthetic process; cellular response to fatty acid; bile acid and bile salt transport; nitrogen catabolite activation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; inflammatory response; innate immune response; signal transduction; steroid hormone mediated signaling pathway; fatty acid homeostasis; positive regulation of insulin receptor signaling pathway; cellular response to lipopolysaccharide; negative regulation of interleukin-2 production; positive regulation of insulin secretion involved in cellular response to glucose stimulus; negative regulation of inflammatory response; glucose homeostasis; negative regulation of NF-kappaB transcription factor activity; positive regulation of adipose tissue development; cell-cell junction assembly; toll-like receptor 9 signaling pathway; negative regulation of monocyte chemotactic protein-1 production; bile acid metabolic process; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of tumor necrosis factor-mediated signaling pathway; defense response to bacterium; negative regulation of interleukin-1 production; negative regulation of tumor necrosis factor production; negative regulation of interleukin-6 production; triglyceride homeostasis; negative regulation of interferon-gamma production; regulation of transcription, DNA-templated; bile acid signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of phosphatidic acid biosynthetic process; cholesterol homeostasis; lipid metabolism; multicellular organism development; cell differentiation; lipid homeostasis; cellular glucose homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	9971
	20186
	ENSG00000012504
	ENSMUSG00000047638
	Q96RI1
	Q60641
NM_001206977; NM_001206978; NM_001206979; NM_001206992; NM_001206993;
	NM_005123
	NM_001163504; NM_001163700; NM_009108; NM_001385711
NP_001193906; NP_001193907; NP_001193908; NP_001193921; NP_001193922;
	NP_005114; NP_001193906.1; NP_001193908.1
	NP_001156976; NP_001157172; NP_033134; NP_001372640
	Wikidata
View/Edit Human	View/Edit Mouse

The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4), is a nuclear receptor that is encoded by the NR1H4 gene in humans.

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