Factor V

F5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3S9C, 1CZS, 1CZV, 3P6Z, 3P70
Identifiers
Aliases	F5, FVL, PCCF, RPRGL1, THPH2, coagulation factor V
External IDs	OMIM: 612309 MGI: 88382 HomoloGene: 104 GeneCards: F5
Gene location (Human)
Chr.	Chromosome 1 (human)
End	169,586,588 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	164,047,846 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; pancreatic ductal cell; ; placenta; ; optic nerve; ; monocyte; ; blood; ; gallbladder; ; glomerulus; ; metanephric glomerulus; ; spongy bone;
	Top expressed in
	left lobe of liver; ; ciliary body; ; lacrimal gland; ; blood; ; iris; ; parotid gland; ; right lobe of liver; ; conjunctival fornix; ; gallbladder; ; seminiferous tubule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein binding; copper ion binding;
Cellular component	platelet alpha granule; extracellular vesicle; endoplasmic reticulum lumen; membrane; plasma membrane; extracellular region; COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum-Golgi intermediate compartment membrane; platelet alpha granule lumen; Golgi apparatus; endoplasmic reticulum; Golgi membrane; extracellular space;
Biological process	hemostasis; platelet degranulation; blood coagulation; blood circulation; endoplasmic reticulum to Golgi vesicle-mediated transport; COPII vesicle coating; response to vitamin K; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	2153
	14067
	ENSG00000198734
	ENSMUSG00000026579
	P12259
	O88783
	NM_000130
	NM_007976
	NP_000121
	NP_032002
	Wikidata
View/Edit Human	View/Edit Mouse

Factor V (pronounced factor five) is a protein of the coagulation system, rarely referred to as proaccelerin or labile factor. In contrast to most other coagulation factors, it is not enzymatically active but functions as a cofactor. Deficiency leads to predisposition for hemorrhage, while some mutations (most notably factor V Leiden) predispose for thrombosis.

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