Follicle-stimulating hormone receptor

FSHR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XWD, 4AY9, 4MQW
Identifiers
Aliases	FSHR, FSHR1, FSHRO, LGR1, ODG1, follicle stimulating hormone receptor
External IDs	OMIM: 136435 MGI: 95583 HomoloGene: 117 GeneCards: FSHR
Gene location (Human)
Chr.	Chromosome 2 (human)
End	49,154,527 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	89,508,103 bp
RNA expression pattern
	Top expressed in
	gallbladder; ; thymus; ; right coronary artery; ; urinary bladder; ; myometrium; ; uterine tube; ; right lung; ; right uterine tube; ; left coronary artery; ; monocyte;
	Top expressed in
	cumulus cell; ; Sertoli cell; ; entorhinal cortex; ; extraocular muscle; ; spermatocyte; ; oocyte; ; ovary; ; primary motor cortex; ; inferior colliculus; ; superior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled peptide receptor activity; G protein-coupled receptor activity; signal transducer activity; protein-hormone receptor activity; protein binding; follicle-stimulating hormone receptor activity;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; plasma membrane; intracellular anatomical structure; receptor complex;
Biological process	G protein-coupled receptor signaling pathway; male gonad development; adenylate cyclase-activating G protein-coupled receptor signaling pathway; female gamete generation; primary ovarian follicle growth; regulation of protein kinase A signaling; female gonad development; activation of adenylate cyclase activity; regulation of osteoclast differentiation; spermatogenesis; hormone-mediated signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of phosphatidylinositol 3-kinase signaling; gonad development; signal transduction; positive regulation of adenylate cyclase activity; cellular response to follicle-stimulating hormone stimulus; follicle-stimulating hormone signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2492
	14309
	ENSG00000170820
	ENSMUSG00000032937
	P23945
	P35378
	NM_000145; NM_181446
	NM_013523
	NP_000136; NP_852111
	NP_038551
	Wikidata
View/Edit Human	View/Edit Mouse

The follicle-stimulating hormone receptor or FSH receptor (FSHR) is a transmembrane receptor that interacts with the follicle-stimulating hormone (FSH) and represents a G protein-coupled receptor (GPCR). Its activation is necessary for the hormonal functioning of FSH. FSHRs are found in the ovary, testis, and uterus.

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