FCRL3

FCRL3
Identifiers
Aliases	FCRL3, CD307c, FCRH3, IFGP3, IRTA3, SPAP2, Fc receptor like 3
External IDs	OMIM: 606510 HomoloGene: 76447 GeneCards: FCRL3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	157,700,769 bp
RNA expression pattern
	Top expressed in
	lymph node; ; spleen; ; appendix; ; blood; ; thymus; ; bone marrow cells; ; pancreatic epithelial cell; ; superficial temporal artery; ; pancreatic ductal cell; ; tibialis anterior muscle;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	kinase binding; phosphatase binding; protein phosphatase binding; protein tyrosine kinase binding;
Cellular component	membrane; integral component of membrane; plasma membrane; cell surface;
Biological process	negative regulation of immunoglobulin production; positive regulation of B cell proliferation; regulation of toll-like receptor 9 signaling pathway; positive regulation of MAPK cascade; regulation of B cell differentiation; negative regulation of B cell receptor signaling pathway; regulation of B cell activation; regulation of calcium ion import; positive regulation of protein serine/threonine phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
	115352
	n/a
	ENSG00000160856
	n/a
	Q96P31
	n/a
	NM_001024667; NM_052939; NM_001320333
	n/a
	NP_001307262; NP_443171
	n/a
	Wikidata
View/Edit Human

Fc receptor-like protein 3 is a protein that in humans is encoded by the FCRL3 gene.

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motif (ITAM) and immunoreceptor-tyrosine inhibitory motif (ITIM) in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.

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