PBX1

PBX1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1B72, 1PUF
Identifiers
Aliases	PBX1, PBX homeobox 1, CAKUHED
External IDs	OMIM: 176310 MGI: 97495 HomoloGene: 20574 GeneCards: PBX1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	164,899,296 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	168,259,839 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; optic nerve; ; myometrium; ; canal of the cervix; ; seminal vesicula; ; Brodmann area 23; ; nipple; ; parietal pleura; ; left uterine tube; ; right uterine tube;
	Top expressed in
	habenula; ; vas deferens; ; olfactory bulb; ; external carotid artery; ; median eminence; ; ventral tegmental area; ; internal carotid artery; ; ciliary body; ; lacrimal gland; ; subiculum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein heterodimerization activity; DNA-binding transcription factor activity; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus; transcription regulator complex; nucleoplasm; RNA polymerase II transcription regulator complex;
Biological process	anterior/posterior pattern specification; proximal/distal pattern formation; positive regulation of G2/M transition of mitotic cell cycle; embryonic organ development; embryonic hemopoiesis; negative regulation of DNA-binding transcription factor activity; transcription, DNA-templated; sex differentiation; multicellular organism development; embryonic limb morphogenesis; somatic stem cell population maintenance; regulation of cell population proliferation; adrenal gland development; spleen development; thymus development; positive regulation of cell population proliferation; urogenital system development; regulation of transcription, DNA-templated; regulation of ossification; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; negative regulation of neuron differentiation; embryonic skeletal system development; branching involved in ureteric bud morphogenesis; steroid biosynthetic process; cell differentiation; animal organ morphogenesis; positive regulation of transcription of Notch receptor target;
	Sources:Amigo / QuickGO
Orthologs
	5087
	18514
	ENSG00000185630
	ENSMUSG00000052534
	P40424
	P41778
	NM_001204961; NM_001204963; NM_002585; NM_001353130; NM_001353131
	NM_001291508; NM_001291509; NM_008783; NM_183355
	NP_001191890; NP_001191892; NP_002576; NP_001340059; NP_001340060
	NP_001278437; NP_001278438; NP_032809; NP_899198
	Wikidata
View/Edit Human	View/Edit Mouse

Pre-B-cell leukemia transcription factor 1 is a protein that in humans is encoded by the PBX1 gene. The homologous protein in Drosophila is known as extradenticle, and causes changes in embryonic development.

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