Etazocine

Etazocine (NIH-7856) is an opioid analgesic of the benzomorphan family which was never marketed. It acts as a partial agonist of the opioid receptors, with mixed agonist and antagonist effects. In animal studies, it was shown to induce analgesia, dependency, and respiratory depression, with overall effects similar to those of morphine, but with substantially reduced potency in comparison.

Etazocine
Clinical data
Other namesNIH-7856 ((±)-form);
GPA-208 ((−)-form);
GPA-2087 ((−)-form);
NIH-8178 ((−)-form);
FDA-0487 ((−)-form)
ATC code
  • None
Legal status
Legal status
  • In general: non-regulated
Identifiers
  • 1,2,3,4,5,6-hexahydro-6,11-diethyl-3-methyl-2,6-methano-3-benzazocin-8-ol
    or
    5,7-diethyl-2-hydroxy-2-methyl-6,7-benzomorphan
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC17H25NO
Molar mass259.393 g·mol−1
3D model (JSmol)
  • Oc1ccc3c(c1)[C@@]2([C@H]([C@@H](N(CC2)C)C3)CC)CC
  • InChI=1S/C17H25NO/c1-4-14-16-10-12-6-7-13(19)11-15(12)17(14,5-2)8-9-18(16)3/h6-7,11,14,16,19H,4-5,8-10H2,1-3H3/t14-,16-,17-/m0/s1
  • Key:JYRBQCWXZNDERM-XIRDDKMYSA-N
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