Cetuximab
Cetuximab, sold under the brand name Erbitux, is an epidermal growth factor receptor (EGFR) inhibitor medication used for the treatment of metastatic colorectal cancer and head and neck cancer. Cetuximab is a chimeric (mouse/human) monoclonal antibody given by intravenous infusion.
| Monoclonal antibody | |
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| Type | Whole antibody |
| Source | Chimeric (mouse/human) |
| Target | EGF receptor |
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| Trade names | Erbitux |
| AHFS/Drugs.com | Monograph |
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| Routes of administration | Intravenous |
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| Elimination half-life | 114 hrs |
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| Formula | C6484H10042N1732O2023S36 |
| Molar mass | 145781.92 g·mol−1 |
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In July 2009, the U.S. Food and Drug Administration (FDA) approved cetuximab (Erbitux) for treatment of colon cancer with wild-type KRAS, since it had little or no effect in colorectal tumors harboring a KRAS mutation (this also applied to the EGFR antibody panitumumab). This was the first genetic test to guide treatment of cancer. In July 2012, the FDA approved a real time PCR companion diagnostic test for KRAS, the therascreen KRAS test.
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