Enteropeptidase
Enteropeptidase (also called enterokinase) is an enzyme produced by cells of the duodenum and is involved in digestion in humans and other animals. Enteropeptidase converts trypsinogen (a zymogen) into its active form trypsin, resulting in the subsequent activation of pancreatic digestive enzymes. Absence of enteropeptidase results in intestinal digestion impairment.
| enteropeptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Crystal structure of Enteropeptidase with an
inhibitor | |||||||||
| Identifiers | |||||||||
| EC no. | 3.4.21.9 | ||||||||
| CAS no. | 9014-74-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| protease, serine, 7 (enteropeptidase) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | TMPRSS15 | ||||||
| NCBI gene | 5651 | ||||||
| HGNC | 9490 | ||||||
| OMIM | 606635 | ||||||
| RefSeq | NM_002772 | ||||||
| UniProt | P98073 | ||||||
| Other data | |||||||
| Locus | Chr. 21 q21 | ||||||
| |||||||
Enteropeptidase is a serine protease (EC 3.4.21.9) consisting of a disulfide-linked heavy-chain of 82-140 kDa that anchors enterokinase in the intestinal brush border membrane and a light-chain of 35–62 kDa that contains the catalytic subunit. Enteropeptidase is a part of the chymotrypsin-clan of serine proteases, and is structurally similar to these proteins.
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