Endothelial NOS

NOS3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1M9J, 1M9K, 1M9M, 1M9Q, 1M9R, 1NIW, 2LL7, 3EAH, 3NOS, 2MG5, 4D1O, 4D1P
Identifiers
Aliases	NOS3, ECNOS, eNOS, nitric oxide synthase 3
External IDs	OMIM: 163729 MGI: 97362 HomoloGene: 504 GeneCards: NOS3
Gene location (Human)
Chr.	Chromosome 7 (human)
End	151,014,588 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	24,589,472 bp
RNA expression pattern
	Top expressed in
	spleen; ; upper lobe of left lung; ; left uterine tube; ; left ventricle; ; right lobe of thyroid gland; ; left coronary artery; ; right coronary artery; ; gastric mucosa; ; tibial nerve; ; right lung;
	Top expressed in
	right ventricle; ; subcutaneous adipose tissue; ; white adipose tissue; ; endocardial cushion; ; brown adipose tissue; ; digastric muscle; ; interventricular septum; ; atrium; ; sternocleidomastoid muscle; ; atrioventricular valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	FMN binding; actin monomer binding; flavin adenine dinucleotide binding; scaffold protein binding; arginine binding; tetrahydrobiopterin binding; metal ion binding; calmodulin binding; protein binding; heme binding; NADP binding; oxidoreductase activity; cadmium ion binding; nitric-oxide synthase activity; NADPH-hemoprotein reductase activity;
Cellular component	cytoplasm; endocytic vesicle membrane; cytosol; Golgi apparatus; membrane; Golgi membrane; plasma membrane; caveola; cytoskeleton; nucleus; vesicle membrane;
Biological process	negative regulation of muscle hyperplasia; ovulation from ovarian follicle; positive regulation of guanylate cyclase activity; nitric oxide biosynthetic process; regulation of systemic arterial blood pressure by endothelin; regulation of sodium ion transport; lung development; negative regulation of blood pressure; removal of superoxide radicals; regulation of nitric-oxide synthase activity; mitochondrion organization; response to heat; in utero embryonic development; negative regulation of hydrolase activity; cell redox homeostasis; arginine catabolic process; response to fluid shear stress; regulation of blood pressure; negative regulation of platelet activation; blood vessel remodeling; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; angiogenesis; negative regulation of potassium ion transport; nitric oxide mediated signal transduction; negative regulation of calcium ion transport; smooth muscle hyperplasia; regulation of the force of heart contraction by chemical signal; endothelial cell migration; lipopolysaccharide-mediated signaling pathway; negative regulation of cell population proliferation; vasodilation; positive regulation of blood vessel endothelial cell migration; positive regulation of angiogenesis; aortic valve morphogenesis; pulmonary valve morphogenesis; endocardial cushion morphogenesis; positive regulation of gene expression; homeostasis of number of cells within a tissue; ventricular septum morphogenesis; negative regulation of biomineral tissue development; response to hormone; response to lipopolysaccharide; regulation of nervous system process; positive regulation of Notch signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4846
	18127
	ENSG00000164867
	ENSMUSG00000028978
	P29474
	P70313
	NM_000603; NM_001160109; NM_001160110; NM_001160111
	NM_008713
	NP_000594; NP_001153581; NP_001153582; NP_001153583
	NP_032739
	Wikidata
View/Edit Human	View/Edit Mouse

Endothelial NOS (eNOS), also known as nitric oxide synthase 3 (NOS3) or constitutive NOS (cNOS), is an enzyme that in humans is encoded by the NOS3 gene located in the 7q35-7q36 region of chromosome 7. This enzyme is one of three isoforms that synthesize nitric oxide (NO), a small gaseous and lipophilic molecule that participates in several biological processes. The other isoforms include neuronal nitric oxide synthase (nNOS), which is constitutively expressed in specific neurons of the brain and inducible nitric oxide synthase (iNOS), whose expression is typically induced in inflammatory diseases. eNOS is primarily responsible for the generation of NO in the vascular endothelium, a monolayer of flat cells lining the interior surface of blood vessels, at the interface between circulating blood in the lumen and the remainder of the vessel wall. NO produced by eNOS in the vascular endothelium plays crucial roles in regulating vascular tone, cellular proliferation, leukocyte adhesion, and platelet aggregation. Therefore, a functional eNOS is essential for a healthy cardiovascular system.

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