Ecdysone receptor
The ecdysone receptor is a nuclear receptor found in arthropods, where it controls development and contributes to other processes such as reproduction. The receptor is a non-covalent heterodimer of two proteins, the EcR protein and ultraspiracle protein (USP). It binds to and is activated by ecdysteroids. Insect ecdysone receptors are currently better characterized than those from other arthropods, and mimics of ecdysteroids are used commercially as caterpillar-selective insecticides.
| Ecdysone receptor protein | |||||||
|---|---|---|---|---|---|---|---|
Crystallographic structure of the ligand binding domain of the ecdysone receptor (rainbow color, N-terminus = blue, C-terminus = red) from Heliothis virescens complexed with ponasterone A (space-filling model, carbon = white, oxygen = red). | |||||||
| Identifiers | |||||||
| Organism | |||||||
| Symbol | EcR | ||||||
| Alt. symbols | EcRH, NR1H1 | ||||||
| Entrez | 35540 | ||||||
| PDB | 1R0O More structures | ||||||
| RefSeq (mRNA) | NM_165461 | ||||||
| RefSeq (Prot) | NP_724456 | ||||||
| UniProt | P34021 | ||||||
| Other data | |||||||
| Chromosome | 2R: 1.97 - 2.07 Mb | ||||||
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| Ultraspiracle protein | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | USP | ||||||
| Alt. symbols | Cf1, NR2B4 | ||||||
| Entrez | 31165 | ||||||
| PDB | 1HG4 More structures | ||||||
| RefSeq (mRNA) | NM_057433 | ||||||
| RefSeq (Prot) | NP_476781 | ||||||
| UniProt | P20153 | ||||||
| Other data | |||||||
| Chromosome | X: 1.93 - 1.94 Mb | ||||||
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