ENU

ENU, also known as N-ethyl-N-nitrosourea (chemical formula C3H7N3O2), is a highly potent mutagen. For a given gene in mice, ENU can induce 1 new mutation in every 700 loci. It is also toxic at high doses.

For other uses, see ENU (disambiguation).
ENU
Names
Preferred IUPAC name
N-Ethyl-N-nitrosourea
Other names
  • N-Ethylnitrosourea
  • 1-Ethyl-1-nitrosourea
  • Nitrosoethylurea
  • N-Nitroso-N-Ethylurea
Identifiers
3D model (JSmol)
Abbreviations ENU
1761174
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.010.975
EC Number
  • 212-072-2
KEGG
RTECS number
  • YT3150000
UNII
UN number 2811
  • InChI=1S/C3H7N3O2/c1-2-6(5-8)3(4)7/h2H2,1H3,(H2,4,7) Y
    Key: FUSGACRLAFQQRL-UHFFFAOYSA-N Y
  • CCN(N=O)C(N)=O
Properties
C3H7N3O2
Molar mass 117.108 g·mol−1
log P 0.208
Vapor pressure 0.00244 kPa @ 25˚C
Acidity (pKa) 12.317
Basicity (pKb) 1.680
Absorbance ε398 = 11.86 mM−1 cm−1
Hazards
GHS labelling:
Danger
H301, H312, H332, H350, H360
P280, P308+P313
Lethal dose or concentration (LD, LC):
300 mg kg−1 (oral, rat)
Related compounds
Related ureas
Related compounds
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

The chemical is an alkylating agent, and acts by transferring the ethyl group of ENU to nucleobases (usually thymine) in nucleic acids. Its main targets are the spermatogonial stem cells, from which mature sperm are derived.

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