EMR1

ADGRE1
Identifiers
Aliases	ADGRE1, TM7LN3, EMR1, adhesion G protein-coupled receptor E1
External IDs	OMIM: 600493 MGI: 106912 HomoloGene: 1493 GeneCards: ADGRE1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	6,940,459 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	57,790,527 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; spleen; ; bone marrow; ; appendix; ; right lung; ; bone marrow cells; ; palpebral conjunctiva; ; upper lobe of left lung; ; gallbladder;
	Top expressed in
	calvaria; ; spleen; ; right ventricle; ; ankle joint; ; carotid body; ; internal carotid artery; ; submandibular gland; ; external carotid artery; ; cervix; ; intercostal muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; external side of plasma membrane; cell periphery; intracellular anatomical structure;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; cell adhesion; adaptive immune response; signal transduction; immune system process; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2015
	13733
	ENSG00000174837
	ENSMUSG00000004730
	Q14246
	Q61549
	NM_001256252; NM_001256253; NM_001256254; NM_001256255; NM_001974
	NM_010130; NM_001355722; NM_001355723
	NP_001243181; NP_001243182; NP_001243183; NP_001243184; NP_001965
	NP_034260; NP_001342651; NP_001342652
	Wikidata
View/Edit Human	View/Edit Mouse

EGF-like module-containing mucin-like hormone receptor-like 1 also known as F4/80 is a protein encoded by the ADGRE1 gene. EMR1 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

EMR1 expression in human is restricted to eosinophils and is a specific marker for these cells. The murine homolog of EMR1, F4/80, is a well-known and widely used marker of murine macrophage populations. The N-terminal fragment (NTF) of EMR1 contains 4-6 Epidermal Growth Factor-like (EGF-like) domains in human and 4-7 EGF-like domains in the mouse.

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