Protein kinase R

EIF2AK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3UIU, 1QU6, 2A19, 2A1A
Identifiers
Aliases	EIF2AK2, PKR, PPP1R83, PRKR, eukaryotic translation initiation factor 2 alpha kinase 2, LEUDEN, DYT33
External IDs	OMIM: 176871 MGI: 1353449 HomoloGene: 48134 GeneCards: EIF2AK2
EC number	2.7.10.2
Gene location (Human)
Chr.	Chromosome 2 (human)
End	37,157,522 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	79,190,002 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; endothelial cell; ; parietal pleura; ; trigeminal ganglion; ; entorhinal cortex; ; postcentral gyrus; ; visceral pleura; ; germinal epithelium; ; spinal ganglia; ; seminal vesicula;
	Top expressed in
	medullary collecting duct; ; duodenum; ; uterus; ; left colon; ; ileum; ; spermatid; ; aortic valve; ; jejunum; ; calvaria; ; seminal vesicula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; non-membrane spanning protein tyrosine kinase activity; kinase activity; protein serine/threonine kinase activity; protein binding; double-stranded RNA binding; protein tyrosine kinase activity; ATP binding; eukaryotic translation initiation factor 2alpha kinase activity; protein phosphatase regulator activity; RNA binding; identical protein binding;
Cellular component	cytoplasm; ribosome; membrane; perinuclear region of cytoplasm; nucleus; cytosol; cytosolic ribosome;
Biological process	negative regulation of translation; regulation of hematopoietic stem cell proliferation; regulation of transcription, DNA-templated; protein biosynthesis; positive regulation of cytokine production; immune system process; phosphorylation; cellular response to amino acid starvation; negative regulation of apoptotic process; positive regulation of NIK/NF-kappaB signaling; transcription, DNA-templated; endoplasmic reticulum unfolded protein response; protein phosphorylation; negative regulation of viral genome replication; regulation of hematopoietic stem cell differentiation; regulation of hematopoietic progenitor cell differentiation; positive regulation of NF-kappaB transcription factor activity; defense response to virus; response to interferon-alpha; positive regulation of chemokine production; negative regulation of osteoblast proliferation; protein autophosphorylation; regulation of NLRP3 inflammasome complex assembly; peptidyl-tyrosine phosphorylation; innate immune response; viral process; response to toxic substance; positive regulation of stress-activated MAPK cascade; response to virus; regulation of translational initiation by eIF2 alpha phosphorylation; regulation of apoptotic process; negative regulation of cell population proliferation; regulation of phosphoprotein phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
	5610
	19106
	ENSG00000055332
	ENSMUSG00000024079
	P19525
	Q03963
	NM_001135651; NM_001135652; NM_002759
	NM_011163
	NP_001129123; NP_001129124; NP_002750
	NP_035293
	Wikidata
View/Edit Human	View/Edit Mouse

Protein kinase RNA-activated also known as protein kinase R (PKR), interferon-induced, double-stranded RNA-activated protein kinase, or eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) is an enzyme that in humans is encoded by the EIF2AK2 gene on chromosome 2. PKR is a serine/tyrosine kinase that is 551 amino acids long.

PKR is inducible by various mechanisms of stress and protects against viral infections. It also has a role in several signaling pathways.

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