EIF1

EIF1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2IF1, 4KZX, 4KZY
Identifiers
Aliases	EIF1, A121, EIF-1, ISO1, SUI1, eukaryotic translation initiation factor 1, Eukaryotic initiation factor 1
External IDs	HomoloGene: 130538 GeneCards: EIF1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,692,668 bp
RNA expression pattern
	Top expressed in
	sperm; ; oocyte; ; parotid gland; ; parietal pleura; ; lower lobe of lung; ; secondary oocyte; ; vena cava; ; caput epididymis; ; visceral pleura; ; corpus epididymis;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	translation factor activity, RNA binding; translation initiation factor activity; RNA binding; protein binding; ribosomal small subunit binding;
Cellular component	cytoplasm; nucleus; eukaryotic 43S preinitiation complex;
Biological process	translational initiation; response to stress; dosage compensation by inactivation of X chromosome; protein biosynthesis; regulation of translational initiation;
	Sources:Amigo / QuickGO
Orthologs
	10209
	n/a
	ENSG00000173812
	n/a
	P41567
	n/a
	NM_005801
	n/a
	NP_005792
	n/a
	Wikidata
View/Edit Human

Eukaryotic translation initiation factor 1 (eIF1) is a protein that in humans is encoded by the EIF1 gene. It is related to yeast SUI1.

eIF1 interacts with the eukaryotic small (40S) ribosomal subunit and eIF3, and is a component of the 43S preinitiation complex (PIC). eIF1 and eIF1A bind cooperatively to the 40S to stabilize an "open" conformation of the preinitiation complex (PIC) during eukaryotic translation initiation. eIF1 binds to a region near the ribosomal P-site in the 40S subunit and functions in a manner similar to the structurally related bacterial counterpart IF3.

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