EGR2

EGR2
Identifiers
Aliases	EGR2, AT591, CMT1D, CMT4E, KROX20, early growth response 2, CHN1
External IDs	OMIM: 129010 MGI: 95296 HomoloGene: 20123 GeneCards: EGR2
Gene location (Human)
Chr.	Chromosome 10 (human)
End	62,819,167 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	67,542,188 bp
RNA expression pattern
	Top expressed in
	gallbladder; ; tibial nerve; ; monocyte; ; gastric mucosa; ; smooth muscle tissue; ; sural nerve; ; skin of abdomen; ; lymph node; ; appendix; ; anterior pituitary;
	Top expressed in
	neuromere; ; rhombomere; ; lip; ; zone of skin; ; spinal nerve; ; ureter; ; urethra; ; thymus; ; male urethra; ; basal forebrain;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; HMG box domain binding; DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; nucleic acid binding; ubiquitin protein ligase binding; transferase activity; DNA-binding transcription factor activity, RNA polymerase II-specific; SUMO ligase activity;
Cellular component	cytoplasm; nucleus; nucleoplasm; intracellular membrane-bounded organelle;
Biological process	cellular response to organic substance; rhythmic behavior; peripheral nervous system development; regulation of transcription, DNA-templated; rhombomere 3 development; brain segmentation; transcription by RNA polymerase II; protein sumoylation; rhombomere 3 formation; transcription, DNA-templated; response to insulin; positive regulation of transcription, DNA-templated; brain development; rhombomere 5 formation; protein export from nucleus; learning or memory; skeletal muscle cell differentiation; Schwann cell differentiation; regulation of neuronal synaptic plasticity; myelination; facial nerve structural organization; regulation of ossification; motor neuron axon guidance; fat cell differentiation; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	1959
	13654
	ENSG00000122877
	ENSMUSG00000037868
	P11161
	P08152
	NM_000399; NM_001136177; NM_001136178; NM_001136179; NM_001321037
	NM_010118; NM_001347458
	NP_000390; NP_001129649; NP_001129650; NP_001129651; NP_001307966
NP_001334387; NP_034248; NP_001360912; NP_001360914; NP_001360915;
	NP_001360916
	Wikidata
View/Edit Human	View/Edit Mouse

Early growth response protein 2 is a protein that in humans is encoded by the EGR2 gene. EGR2 (also termed Krox20) is a transcription regulatory factor, containing three zinc finger DNA-binding sites, and is highly expressed in a population of migrating neural crest cells. It is later expressed in the neural crest derived cells of the cranial ganglion. The protein encoded by Krox20 contains two cys2his2-type zinc fingers. Krox20 gene expression is restricted to the early hindbrain development. It is evolutionarily conserved in vertebrates, humans, mice, chicks, and zebra fish. In addition, the amino acid sequence and most aspects of the embryonic gene pattern is conserved among vertebrates, further implicating its role in hindbrain development. When the Krox20 is deleted in mice, the protein coding ability of the Krox20 gene (including the DNA-binding domain of the zinc finger) is diminished. These mice are unable to survive after birth and exhibit major hindbrain defects. These defects include but are not limited to defects in formation of cranial sensory ganglia, partial fusion of the trigeminal nerve (V) with the facial (VII) and auditory (VII) nerves, the proximal nerve roots coming off of these ganglia were disorganized and intertwined among one another as they entered the brainstem, and there was fusion of the glossopharyngeal (IX) nerve complex.

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