EF-Tu
EF-Tu (elongation factor thermo unstable) is a prokaryotic elongation factor responsible for catalyzing the binding of an aminoacyl-tRNA (aa-tRNA) to the ribosome. It is a G-protein, and facilitates the selection and binding of an aa-tRNA to the A-site of the ribosome. As a reflection of its crucial role in translation, EF-Tu is one of the most abundant and highly conserved proteins in prokaryotes. It is found in eukaryotic mitochondria as TUFM.
| Elongation Factor Thermo Unstable | |||||||||
|---|---|---|---|---|---|---|---|---|---|
EF-Tu (blue) complexed with tRNA (red) and GTP (yellow) | |||||||||
| Identifiers | |||||||||
| Symbol | EF-Tu | ||||||||
| Pfam | GTP_EFTU | ||||||||
| Pfam clan | CL0023 | ||||||||
| InterPro | IPR004541 | ||||||||
| PROSITE | PDOC00273 | ||||||||
| CATH | 1ETU | ||||||||
| SCOP2 | 1ETU / SCOPe / SUPFAM | ||||||||
| CDD | cd00881 | ||||||||
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| EF-Tu | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | GTP_EFTU_D2 | ||||||||
| Pfam | PF03144 | ||||||||
| InterPro | IPR004161 | ||||||||
| CDD | cd01342 | ||||||||
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| Elongation factor Tu domain 3 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | GTP_EFTU_D3 | ||||||||
| Pfam | PF03143 | ||||||||
| InterPro | IPR004160 | ||||||||
| CDD | cd01513 | ||||||||
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As a family of elongation factors, EF-Tu also includes its eukaryotic and archaeal homolog, the alpha subunit of eEF-1 (EF-1A).
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