EEA1

EEA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HYI, 1HYJ, 1JOC, 3MJH
Identifiers
Aliases	EEA1, MST105, MSTP105, ZFYVE2, early endosome antigen 1
External IDs	OMIM: 605070 MGI: 2442192 HomoloGene: 37822 GeneCards: EEA1
Gene location (Human)
Chr.	Chromosome 12 (human)
End	92,929,331 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	95,881,380 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; biceps brachii; ; cavity of mouth; ; human penis; ; urethra; ; synovial joint; ; jejunal mucosa; ; lactiferous duct; ; right ventricle; ; vulva;
	Top expressed in
	secondary oocyte; ; plantaris muscle; ; extensor digitorum longus muscle; ; soleus muscle; ; left colon; ; paraventricular nucleus of hypothalamus; ; calvaria; ; left lung lobe; ; dorsomedial hypothalamic nucleus; ; cingulate gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein homodimerization activity; zinc ion binding; metal ion binding; calmodulin binding; GTP-dependent protein binding; 1-phosphatidylinositol binding; protein binding; nucleic acid binding;
Cellular component	cytoplasm; recycling endosome; cytosol; endosome; early endosome membrane; membrane; axonal spine; serine-pyruvate aminotransferase complex; early endosome; extrinsic component of plasma membrane; extracellular exosome; cytoplasmic vesicle; presynapse; synapse;
Biological process	endocytosis; early endosome to late endosome transport; synaptic vesicle to endosome fusion; vesicle fusion;
	Sources:Amigo / QuickGO
Orthologs
	8411
	216238
	ENSG00000102189
	ENSMUSG00000036499
	Q15075
	Q8BL66
	NM_003566
	NM_001001932
	NP_003557
	NP_001001932
	Wikidata
View/Edit Human	View/Edit Mouse

The gene EEA1 encodes for the 1400 amino acid protein, Early Endosome Antigen 1.

EEA1 localizes exclusively to early endosomes and has an important role in endosomal trafficking. EEA1 binds directly to the phospholipid phosphatidylinositol 3-phosphate through its C-terminal FYVE domain and forms a homodimer through a coiled coil. EEA1 acts as a tethering molecule that couples vesicle docking with SNAREs such as N-ethylmaleimide sensitive fusion protein, bringing the endosomes physically closer and ultimately resulting in the fusion and delivery of endosomal cargo.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.