Excitatory amino acid transporter 2

SLC1A2
Identifiers
Aliases	SLC1A2, EAAT2, GLT-1, HBGT, solute carrier family 1 member 2, EIEE41, DEE41
External IDs	OMIM: 600300 MGI: 101931 HomoloGene: 3075 GeneCards: SLC1A2
Gene location (Human)
Chr.	Chromosome 11 (human)
End	35,420,063 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	102,621,129 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; entorhinal cortex; ; external globus pallidus; ; middle temporal gyrus; ; parietal lobe; ; postcentral gyrus; ; internal globus pallidus; ; nucleus accumbens; ; caudate nucleus;
	Top expressed in
	olfactory tubercle; ; subiculum; ; globus pallidus; ; mammillary body; ; medial dorsal nucleus; ; medial geniculate nucleus; ; ventral tegmental area; ; medial vestibular nucleus; ; dorsal tegmental nucleus; ; ventromedial nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	anion transmembrane transporter activity; protein binding; symporter activity; L-glutamate transmembrane transporter activity; amino acid transmembrane transporter activity; glutamate:sodium symporter activity; high-affinity glutamate transmembrane transporter activity; metal ion binding;
Cellular component	integral component of membrane; membrane; plasma membrane; cell surface; axon; axolemma; integral component of plasma membrane; glutamatergic synapse; integral component of presynaptic membrane;
Biological process	cellular response to extracellular stimulus; chemical synaptic transmission; positive regulation of glucose import; response to amino acid; response to light stimulus; multicellular organism growth; D-aspartate import across plasma membrane; ion transport; nervous system development; glutamate secretion; telencephalon development; anion transmembrane transport; adult behavior; response to wounding; multicellular organism aging; visual behavior; protein homotrimerization; L-glutamate import across plasma membrane; amino acid transport; L-glutamate transmembrane transport; neurotransmitter reuptake;
	Sources:Amigo / QuickGO
Orthologs
	6506
	20511
	ENSG00000110436
	ENSMUSG00000005089
	P43004
	P43006
	NM_001195728; NM_001252652; NM_004171
	NM_001077514; NM_001077515; NM_011393; NM_001361018
	NP_001182657; NP_001239581; NP_004162
	NP_001070982; NP_001070983; NP_035523; NP_001347947
	Wikidata
View/Edit Human	View/Edit Mouse

Excitatory amino acid transporter 2 (EAAT2) also known as solute carrier family 1 member 2 (SLC1A2) and glutamate transporter 1 (GLT-1) is a protein that in humans is encoded by the SLC1A2 gene. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.