Dual oxidase 2

DUOX2
Identifiers
Aliases	DUOX2, LNOX2, NOXEF2, P138-TOX, TDH6, THOX2, dual oxidase 2
External IDs	OMIM: 606759 MGI: 3036280 HomoloGene: 9689 GeneCards: DUOX2
Gene location (Human)
Chr.	Chromosome 15 (human)
End	45,114,172 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	122,128,930 bp
RNA expression pattern
	Top expressed in
	gallbladder; ; palpebral conjunctiva; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; gastric mucosa; ; islet of Langerhans; ; appendix; ; sperm; ; pancreatic epithelial cell; ; vagina;
	Top expressed in
	ileum; ; jejunum; ; colon; ; duodenum; ; stomach; ; urinary bladder; ; esophagus; ; pancreas; ; mouth; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; peroxidase activity; metal ion binding; heme binding; oxidoreductase activity; NAD(P)H oxidase H2O2-forming activity; protein binding; superoxide-generating NAD(P)H oxidase activity;
Cellular component	integral component of membrane; membrane; plasma membrane; cell junction; apical plasma membrane; extracellular exosome; endoplasmic reticulum; cytosol; cell surface; cell leading edge; apical part of cell; NADPH oxidase complex;
Biological process	cuticle development; bone mineralization; multicellular organism growth; cytokine-mediated signaling pathway; cellular oxidant detoxification; response to virus; response to oxidative stress; thyroid hormone metabolic process; thyroid hormone generation; thyroid gland development; hydrogen peroxide catabolic process; fertilization; inner ear development; response to cAMP; adenohypophysis morphogenesis; hormone metabolic process; hormone biosynthetic process; hydrogen peroxide biosynthetic process; superoxide anion generation; positive regulation of wound healing; positive regulation of cell motility; defense response;
	Sources:Amigo / QuickGO
Orthologs
	50506
	214593
	ENSG00000140279
	ENSMUSG00000068452
	Q9NRD8
	A2AQ99
	NM_014080; NM_001363711
	NM_177610; NM_001362755
	NP_054799; NP_001350640
	NP_808278; NP_001349684
	Wikidata
View/Edit Human	View/Edit Mouse

Dual oxidase 2, also known as DUOX2 or ThOX2 (for thyroid oxidase), is an enzyme that in humans is encoded by the DUOX2 gene. Dual oxidase is an enzyme that was first identified in the mammalian thyroid gland. In humans, two isoforms are found; hDUOX1 and hDUOX2 (this enzyme). The protein location is not exclusive to thyroid tissue; hDUOX1 is prominent in airway epithelial cells and hDUOX2 in the salivary glands and gastrointestinal tract.

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