Ditolylguanidine

Ditolylguanidine
Clinical data
ATC code	none;
Identifiers
	IUPAC name 1,2-bis(2-methylphenyl)guanidine;
CAS Number	97-39-2 ;
PubChem CID	7333;
IUPHAR/BPS	6684;
ChemSpider	7056 ;
UNII	LL2P01I17O;
ChEMBL	ChEMBL282433 ;
CompTox Dashboard (EPA)	DTXSID2026606 ;
ECHA InfoCard	100.002.344
Chemical and physical data
Formula	C15H17N3
Molar mass	239.322 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N(=C(/Nc1ccccc1C)N)\c2ccccc2C;
	InChI InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18) ; Key:OPNUROKCUBTKLF-UHFFFAOYSA-N ;
	(verify)

Ditolylguanidine is a sigma receptor agonist. It is somewhat selective for sigma receptors, but non-selective between the two sigma receptor subtypes, binding to both σ1 and σ2 with equal affinity. It has neuroprotective and antidepressant effects, and potentiates the effects of NMDA antagonists.

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