δ-opioid receptor

OPRD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4N6H, 4RWA, 4RWD
Identifiers
Aliases	OPRD1, OPRD, Δ-opioid receptor, opioid receptor delta 1, DOP, DOR1, DOR
External IDs	OMIM: 165195 MGI: 97438 HomoloGene: 20252 GeneCards: OPRD1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	28,871,267 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	131,871,797 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; islet of Langerhans; ; prefrontal cortex; ; middle temporal gyrus; ; superior frontal gyrus; ; Brodmann area 23; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; postcentral gyrus; ; cingulate gyrus;
	Top expressed in
	pituitary stalk; ; secondary oocyte; ; superior frontal gyrus; ; outer nuclear layer; ; inner nuclear layer; ; cerebellar cortex; ; globus pallidus; ; trigeminal ganglion; ; respiratory epithelium; ; nose;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled enkephalin receptor activity; G protein-coupled receptor activity; neuropeptide binding; signal transducer activity; G protein-coupled opioid receptor activity; protein binding; receptor serine/threonine kinase binding; peptide binding;
Cellular component	cytoplasm; axon terminus; integral component of membrane; vesicle; postsynaptic membrane; membrane; intrinsic component of plasma membrane; plasma membrane; integral component of plasma membrane; dendrite membrane; membrane raft; neuron projection; integral component of synaptic vesicle membrane; spine apparatus; neuronal dense core vesicle; integral component of presynaptic membrane; integral component of postsynaptic density membrane;
Biological process	regulation of calcium ion transport; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; regulation of sensory perception of pain; eating behavior; adult locomotory behavior; negative regulation of protein oligomerization; cellular response to growth factor stimulus; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; cellular response to toxic substance; negative regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; regulation of mitochondrial membrane potential; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of CREB transcription factor activity; G protein-coupled opioid receptor signaling pathway; immune response; neuropeptide signaling pathway; cellular response to hypoxia; signal transduction; chemical synaptic transmission; sensory perception of pain; G protein-coupled receptor signaling pathway; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4985
	18386
	ENSG00000116329
	ENSMUSG00000050511
	P41143
	P32300
	NM_000911
	NM_013622
	NP_000902
	NP_038650
	Wikidata
View/Edit Human	View/Edit Mouse

The δ-opioid receptor, also known as delta opioid receptor or simply delta receptor, abbreviated DOR or DOP, is an inhibitory 7-transmembrane G-protein coupled receptor coupled to the G protein G_i/G₀ and has enkephalins as its endogenous ligands. The regions of the brain where the δ-opioid receptor is largely expressed vary from species model to species model. In humans, the δ-opioid receptor is most heavily expressed in the basal ganglia and neocortical regions of the brain.

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