Deferoxamine

Deferoxamine
	Skeletal formula and spacefill model of deferoxamine
Clinical data
Trade names	Desferal
Other names	desferrioxamine B, desferoxamine B, DFO-B, DFB ,N'-[5-(Acetyl-hydroxy-amino)pentyl]-N-[5-[3-(5-aminopentyl-hydroxy-carbamoyl) propanoylamino]pentyl]-N-hydroxy-butane diamide
AHFS/Drugs.com	Monograph
Routes of; administration	intramuscular; intravenous; subcutaneous;
ATC code	V03AC01 (WHO) ;
Pharmacokinetic data
Elimination half-life	6 hours
Identifiers
	IUPAC name N'-{5-[Acetyl(hydroxy)amino]pentyl}-N-[5-({4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoyl}amino)pentyl]-N-hydroxysuccinamide;
CAS Number	70-51-9 ;
PubChem CID	2973;
DrugBank	DB00746;
ChemSpider	2867;
UNII	J06Y7MXW4D;
KEGG	D03670;
ChEBI	CHEBI:4356;
ChEMBL	ChEMBL556;
CompTox Dashboard (EPA)	DTXSID7022887 ;
ECHA InfoCard	100.000.671
Chemical and physical data
Formula	C25H48N6O8
Molar mass	560.693 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN;
	InChI InChI=1S/C25H48N6O8/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34); ; Key:UBQYURCVBFRUQT-UHFFFAOYSA-N;

Deferoxamine (DFOA), also known as desferrioxamine and sold under the brand name Desferal, is a medication that binds iron and aluminium. It is specifically used in iron overdose, hemochromatosis either due to multiple blood transfusions or an underlying genetic condition, and aluminium toxicity in people on dialysis. It is used by injection into a muscle, vein, or under the skin.

Common side effects include pain at the site of injection, diarrhea, vomiting, fever, hearing loss, and eye problems. Severe allergic reactions including anaphylaxis and low blood pressure may occur. It is unclear if use during pregnancy or breastfeeding is safe for the baby. Deferoxamine is a siderophore from the bacteria Streptomyces pilosus.

Deferoxamine was approved for medical use in the United States in 1968. It is on the World Health Organization's List of Essential Medicines.

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