Death receptor 6

TNFRSF21
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3QO4, 3U3P, 3U3Q, 3U3S, 3U3T, 3U3V, 2DBH
Identifiers
Aliases	TNFRSF21, BM-018, CD358, DR6, tumor necrosis factor receptor superfamily member 21, TNF receptor superfamily member 21
External IDs	OMIM: 605732 MGI: 2151075 HomoloGene: 8696 GeneCards: TNFRSF21
Gene location (Human)
Chr.	Chromosome 6 (human)
End	47,309,905 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	43,400,080 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; mucosa of urinary bladder; ; periodontal fiber; ; subthalamic nucleus; ; inferior ganglion of vagus nerve; ; pons; ; bronchial epithelial cell; ; medulla oblongata; ; superior vestibular nucleus; ; gums;
	Top expressed in
	epithelium of stomach; ; pyloric antrum; ; proximal tubule; ; mucous cell of stomach; ; kidney; ; facial motor nucleus; ; anterior horn of spinal cord; ; stria vascularis; ; dorsomedial hypothalamic nucleus; ; ciliary body;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	tumor necrosis factor-activated receptor activity;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; axon; plasma membrane; intrinsic component of plasma membrane; cytoplasm;
Biological process	regulation of apoptotic process; immune system process; cellular response to tumor necrosis factor; response to lipopolysaccharide; regulation of cell population proliferation; immune response; apoptotic signaling pathway; inflammatory response; negative regulation of myelination; signal transduction; apoptotic process; oligodendrocyte apoptotic process; negative regulation of B cell proliferation; neuron apoptotic process; humoral immune response; myelination; negative regulation of T cell proliferation; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; B cell apoptotic process; adaptive immune response; regulation of oligodendrocyte differentiation; regulation of lipid metabolic process; axonal fasciculation;
	Sources:Amigo / QuickGO
Orthologs
	27242
	94185
	ENSG00000146072
	ENSMUSG00000023915
	O75509
	Q9EPU5
	NM_014452
	NM_178589
	NP_055267
	NP_848704
	Wikidata
View/Edit Human	View/Edit Mouse

Death receptor 6 (DR6), also known as tumor necrosis factor receptor superfamily member 21 (TNFRSF21), is a cell surface receptor of the tumor necrosis factor receptor superfamily which activates the JNK and NF-κB pathways. It is mostly expressed in the thymus, spleen and white blood cells. The Gene for DR6 is 78,450 bases long and is found on the 6th chromosome. This is transcribed into a 655 amino acid chain weighing 71.8 kDa. Post transcriptional modifications of this protein include glycosylation on the asparagines at the 82, 141, 252, 257, 278, and 289 amino acid locations.

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