Darifenacin

Darifenacin
Clinical data
Trade names	Enablex, Emselex
AHFS/Drugs.com	Monograph
MedlinePlus	a605039
Pregnancy; category	AU: B3;
Routes of; administration	By mouth
ATC code	G04BD10 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only; EU: Rx-only;
Pharmacokinetic data
Bioavailability	15 to 19% (dose-dependent)
Protein binding	98%
Metabolism	Liver (CYP2D6- and CYP3A4-mediated)
Elimination half-life	13 to 19 hours
Excretion	Kidney (60%) and biliary (40%)
Identifiers
	IUPAC name (S)-2-[1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl] pyrrolidin-3-yl] -2,2-diphenyl-acetamide;
CAS Number	133099-04-4 ;
PubChem CID	444031;
IUPHAR/BPS	321;
DrugBank	DB00496 ;
ChemSpider	392054 ;
UNII	APG9819VLM;
KEGG	D03654 ; as salt: D01699 ;
ChEBI	CHEBI:391960 ;
ChEMBL	ChEMBL1346 ;
CompTox Dashboard (EPA)	DTXSID2048290 ;
ECHA InfoCard	100.118.382
Chemical and physical data
Formula	C28H30N2O2
Molar mass	426.560 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(N)C(c1ccccc1)(c2ccccc2)[C@H]3CN(CC3)CCc5cc4c(OCC4)cc5;
	InChI InChI=1S/C28H30N2O2/c29-27(31)28(23-7-3-1-4-8-23,24-9-5-2-6-10-24)25-14-17-30(20-25)16-13-21-11-12-26-22(19-21)15-18-32-26/h1-12,19,25H,13-18,20H2,(H2,29,31)/t25-/m1/s1 ; Key:HXGBXQDTNZMWGS-RUZDIDTESA-N ;
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Darifenacin (trade name Enablex in United States and Canada, Emselex in the European Union) is a medication used to treat urinary incontinence due to an overactive bladder. It was discovered by scientists at the Pfizer research site in Sandwich, UK under the identifier UK-88,525 and used to be marketed by Novartis. In 2010, the US rights were sold to Warner Chilcott for US$400 million.

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