DYRK3

DYRK3
Identifiers
Aliases	DYRK3, DYRK5, RED, REDK, hYAK3-2, dual specificity tyrosine phosphorylation regulated kinase 3
External IDs	OMIM: 603497 MGI: 1330300 HomoloGene: 55762 GeneCards: DYRK3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	206,684,419 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	131,066,077 bp
RNA expression pattern
	Top expressed in
	sperm; ; vena cava; ; stromal cell of endometrium; ; mucosa of urinary bladder; ; left ventricle; ; gallbladder; ; lactiferous duct; ; smooth muscle tissue; ; embryo; ; gastric mucosa;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; respiratory epithelium; ; olfactory epithelium; ; parotid gland; ; facial motor nucleus; ; bone marrow; ; endocardial cushion; ; Region I of hippocampus proper;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; nucleotide binding; ATP binding; magnesium ion binding; metal ion binding; kinase activity; protein serine/threonine kinase activity;
Cellular component	nucleus; nucleoplasm; cytosol; intracellular membrane-bounded organelle; cytoplasm; cytoplasmic stress granule; pericentriolar material; microtubule organizing center; cytoskeleton; nuclear speck;
Biological process	erythrocyte differentiation; protein phosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; stress granule disassembly; negative regulation of apoptotic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; regulation of cellular response to stress; regulation of TORC1 signaling; cell cycle; nuclear speck organization; cell division; positive regulation of cell cycle G2/M phase transition; organelle disassembly;
	Sources:Amigo / QuickGO
Orthologs
	8444
	226419
	ENSG00000143479
	ENSMUSG00000016526
	O43781
	Q922Y0
	NM_001004023; NM_003582
	NM_145508
	NP_001004023; NP_003573
	NP_663483
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity tyrosine-phosphorylation-regulated kinase 3 is an enzyme that in humans is encoded by the DYRK3 gene.

This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified.

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