DNA-PKcs

PRKDC
Identifiers
Aliases	PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350, IMD26, protein kinase, DNA-activated, catalytic polypeptide, DNA-PKC, protein kinase, DNA-activated, catalytic subunit, DNAPKc
External IDs	OMIM: 600899 MGI: 104779 HomoloGene: 5037 GeneCards: PRKDC
Gene location (Human)
Chr.	Chromosome 8 (human)
End	47,960,178 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	15,660,099 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; ganglionic eminence; ; cavity of mouth; ; left uterine tube; ; human penis; ; retinal pigment epithelium; ; skin of abdomen; ; prefrontal cortex; ; canal of the cervix; ; gastrocnemius muscle;
	Top expressed in
	olfactory tubercle; ; saccule; ; medullary collecting duct; ; Paneth cell; ; cornea; ; lacrimal gland; ; hair follicle; ; nucleus accumbens; ; ureter; ; urothelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; DNA binding; DNA-dependent protein kinase activity; transcription factor binding; kinase activity; protein serine/threonine kinase activity; protein binding; enzyme binding; ATP binding; RNA binding; double-stranded DNA binding; protein kinase activity; protein domain specific binding;
Cellular component	cytosol; membrane; transcription regulator complex; nucleoplasm; DNA-dependent protein kinase-DNA ligase 4 complex; nonhomologous end joining complex; extracellular matrix; nucleus; protein-DNA complex; nucleolus; protein-containing complex;
Biological process	somitogenesis; negative regulation of protein phosphorylation; response to ionizing radiation; negative regulation of response to gamma radiation; positive regulation of immune system process; DNA recombination; positive regulation of developmental growth; T cell differentiation in thymus; telomere capping; phosphorylation; rhythmic process; thymus development; positive regulation of fibroblast proliferation; lymphocyte differentiation; T cell receptor V(D)J recombination; negative regulation of apoptotic process; double-strand break repair via alternative nonhomologous end joining; spleen development; negative regulation of immunoglobulin production; response to activity; regulation of smooth muscle cell proliferation; cellular response to DNA damage stimulus; heart development; pro-B cell differentiation; brain development; B cell lineage commitment; peptidyl-serine phosphorylation; protein destabilization; regulation of circadian rhythm; intrinsic apoptotic signaling pathway in response to DNA damage; V(D)J recombination; cellular response to insulin stimulus; positive regulation of apoptotic process; ectopic germ cell programmed cell death; immunoglobulin V(D)J recombination; cell population proliferation; double-strand break repair via nonhomologous end joining; telomere maintenance; response to gamma radiation; positive regulation of type I interferon production; T cell lineage commitment; positive regulation of transcription by RNA polymerase II; negative regulation of cellular senescence; immunoglobulin production; double-strand break repair; DNA repair; protein ubiquitination; protein phosphorylation; activation of innate immune response; immune system process; innate immune response; regulation of epithelial cell proliferation; positive regulation of double-strand break repair via nonhomologous end joining;
	Sources:Amigo / QuickGO
Orthologs
	5591
	19090
	ENSG00000253729
	ENSMUSG00000022672
	P78527
	P97313
	NM_001081640; NM_006904
	NM_011159
	NP_001075109; NP_008835
	NP_035289
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-dependent protein kinase, catalytic subunit, also known as DNA-PKcs, is an enzyme that in humans is encoded by the gene designated as PRKDC or XRCC7. DNA-PKcs belongs to the phosphatidylinositol 3-kinase-related kinase protein family. The DNA-Pkcs protein is a serine/threonine protein kinase consisting of a single polypeptide chain of 4,128 amino acids.

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