DLG4

DLG4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KEF, 3I4W, 3K82, 3ZRT
Identifiers
Aliases	DLG4, PSD95, SAP-90, SAP90, Dlgh4, PSD-95, SAP90A, discs large homolog 4, discs large MAGUK scaffold protein 4, MRD62
External IDs	OMIM: 602887 MGI: 1277959 HomoloGene: 1047 GeneCards: DLG4
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,219,841 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,938,348 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; cingulate gyrus; ; prefrontal cortex; ; anterior pituitary; ; Brodmann area 9; ; amygdala; ; caudate nucleus; ; ganglionic eminence; ; putamen; ; hypothalamus;
	Top expressed in
	superior frontal gyrus; ; cerebellar cortex; ; entorhinal cortex; ; ventromedial nucleus; ; primary motor cortex; ; hippocampus proper; ; olfactory tubercle; ; lateral hypothalamus; ; mammillary body; ; supraoptic nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	beta-1 adrenergic receptor binding; PDZ domain binding; protein-containing complex binding; scaffold protein binding; guanylate kinase activity; P2Y1 nucleotide receptor binding; acetylcholine receptor binding; kinase binding; protein C-terminus binding; protein binding; ionotropic glutamate receptor binding; D1 dopamine receptor binding; protein phosphatase binding; neuroligin family protein binding; ligand-gated ion channel activity;
Cellular component	cytoplasm; juxtaparanode region of axon; endocytic vesicle membrane; synaptic membrane; postsynaptic membrane; cell projection; membrane; postsynaptic density; synaptic vesicle; extrinsic component of cytoplasmic side of plasma membrane; voltage-gated potassium channel complex; cortical cytoskeleton; plasma membrane; dendritic spine; synapse; excitatory synapse; cerebellar mossy fiber; axon; cell junction; dendrite; basolateral plasma membrane; endoplasmic reticulum; neuron spine; AMPA glutamate receptor complex; dendrite cytoplasm; ionotropic glutamate receptor complex; neuron projection terminus; cell periphery; cytosol; postsynaptic density membrane; postsynapse; neuromuscular junction; neuron projection; glutamatergic synapse;
Biological process	receptor localization to synapse; regulation of grooming behavior; regulation of long-term neuronal synaptic plasticity; neuromuscular process controlling balance; negative regulation of receptor internalization; establishment of protein localization; positive regulation of cytosolic calcium ion concentration; learning; nervous system development; MAPK cascade; locomotory exploration behavior; regulation of NMDA receptor activity; AMPA glutamate receptor clustering; dendritic spine morphogenesis; vocalization behavior; positive regulation of synaptic transmission; establishment or maintenance of epithelial cell apical/basal polarity; positive regulation of excitatory postsynaptic potential; social behavior; synaptic vesicle maturation; protein localization to synapse; signal transduction; GMP metabolic process; GDP metabolic process; chemical synaptic transmission; transmembrane transport; cellular response to potassium ion; receptor clustering; positive regulation of protein tyrosine kinase activity; protein-containing complex assembly; cell-cell adhesion; postsynaptic neurotransmitter receptor diffusion trapping; positive regulation of neuron projection arborization; neurotransmitter receptor localization to postsynaptic specialization membrane;
	Sources:Amigo / QuickGO
Orthologs
	1742
	13385
	ENSG00000132535
	ENSMUSG00000020886
	P78352; O14909
	Q62108
NM_001128827; NM_001365; NM_001321074; NM_001321075; NM_001321076;
	NM_001321077; NM_001369566
NM_001109752; NM_007864; NM_001370671; NM_001370672; NM_001370674;
	NM_001370675
NP_001122299; NP_001308003; NP_001308004; NP_001308005; NP_001308006;
	NP_001356
	NP_001103222; NP_031890
	Wikidata
View/Edit Human	View/Edit Mouse

PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (discs large homolog 4) gene.

PSD-95 is a member of the membrane-associated guanylate kinase (MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels. It plays an important role in synaptic plasticity and the stabilization of synaptic changes during long-term potentiation.

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