DLG1

DLG1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PDR, 2M3M, 2OQS, 2X7Z, 3RL7, 3RL8, 3W9Y, 4AMH, 4G69
Identifiers
Aliases	DLG1, DLGH1, SAP-97, SAP97, dJ1061C18.1.1, hdlg, B130052P05Rik, E-dlg/SAP97, mKIAA4187, discs large homolog 1, scribble cell polarity complex component, discs large MAGUK scaffold protein 1
External IDs	OMIM: 601014 MGI: 107231 HomoloGene: 20869 GeneCards: DLG1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	197,299,330 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	31,693,947 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; corpus callosum; ; inferior olivary nucleus; ; inferior ganglion of vagus nerve; ; subthalamic nucleus; ; hair follicle; ; external globus pallidus; ; Brodmann area 23; ; retinal pigment epithelium; ; postcentral gyrus;
	Top expressed in
	globus pallidus; ; medullary collecting duct; ; primary motor cortex; ; conjunctival fornix; ; olfactory tubercle; ; Paneth cell; ; utricle; ; condyle; ; substantia nigra; ; cerebellar vermis;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	phosphatase binding; phosphoprotein phosphatase activity; transmembrane transporter binding; cytoskeletal protein binding; protein C-terminus binding; ionotropic glutamate receptor binding; kinase binding; mitogen-activated protein kinase kinase binding; guanylate kinase activity; protein binding; molecular adaptor activity; protein kinase binding; L27 domain binding; ligand-gated ion channel activity; potassium channel regulator activity; cadherin binding; structural constituent of postsynaptic density;
Cellular component	cytoplasm; cytosol; postsynaptic membrane; membrane; cell-cell junction; bicellular tight junction; node of Ranvier; synapse; perinuclear region of cytoplasm; cytoplasmic side of plasma membrane; microtubule; nucleus; cell projection membrane; membrane raft; ionotropic glutamate receptor complex; extracellular exosome; Golgi apparatus; lateral plasma membrane; intercalated disc; neuromuscular junction; myelin sheath abaxonal region; lateral loop; endoplasmic reticulum membrane; MPP7-DLG1-LIN7 complex; sarcolemma; postsynaptic density; cell junction; basolateral plasma membrane; plasma membrane; endoplasmic reticulum; immunological synapse; basement membrane; apical plasma membrane; neuron projection; postsynaptic density membrane; glutamatergic synapse;
Biological process	embryonic skeletal system morphogenesis; ureteric bud development; positive regulation of actin filament polymerization; positive regulation of potassium ion transport; negative regulation of p38MAPK cascade; amyloid precursor protein metabolic process; tissue morphogenesis; reproductive structure development; membrane raft organization; hard palate development; endothelial cell proliferation; smooth muscle tissue development; negative regulation of epithelial cell proliferation; regulation of sodium ion transmembrane transport; astral microtubule organization; actin filament organization; mitotic cell cycle checkpoint signaling; receptor clustering; establishment or maintenance of cell polarity; negative regulation of T cell proliferation; branching involved in ureteric bud morphogenesis; regulation of myelination; cortical microtubule organization; establishment or maintenance of epithelial cell apical/basal polarity; viral process; T cell cytokine production; T cell activation; peristalsis; receptor localization to synapse; negative regulation of protein kinase B signaling; regulation of NIK/NF-kappaB signaling; negative regulation of transcription by RNA polymerase II; nervous system development; regulation of cell shape; establishment of centrosome localization; immunological synapse formation; cortical actin cytoskeleton organization; protein localization; lens development in camera-type eye; bicellular tight junction assembly; positive regulation of cell population proliferation; negative regulation of ERK1 and ERK2 cascade; activation of protein kinase activity; negative regulation of mitotic cell cycle; regulation of membrane potential; protein localization to plasma membrane; GDP metabolic process; ion transmembrane transport; protein dephosphorylation; GMP metabolic process; chemical synaptic transmission; regulation of ventricular cardiac muscle cell action potential; regulation of potassium ion import; regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; regulation of potassium ion export across plasma membrane; MAPK cascade; cell-cell adhesion; maintenance of postsynaptic density structure; neurotransmitter receptor localization to postsynaptic specialization membrane; positive regulation of protein localization to plasma membrane; regulation of NMDA receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	1739
	13383
	ENSG00000075711
	ENSMUSG00000022770
	Q12959
	Q811D0
NM_001098424; NM_001204386; NM_001204387; NM_001204388; NM_001290983;
	NM_004087; NM_001363865; NM_001366203; NM_001366204; NM_001366205; NM_001366206; NM_001366207; NM_001366208; NM_001366209; NM_001366210; NM_001366211; NM_001366212; NM_001366213; NM_001366214; NM_001366215; NM_001366216; NM_001366217; NM_001366218; NM_001366219; NM_001366220; NM_001366221; NM_001366222
NM_001252433; NM_001252434; NM_001252435; NM_001252436; NM_007862;
	NM_001357281; NM_001357282
NP_001091894; NP_001191315; NP_001191316; NP_001191317; NP_001277912;
	NP_004078; NP_001350794; NP_001353132; NP_001353133; NP_001353134; NP_001353135; NP_001353136; NP_001353137; NP_001353138; NP_001353139; NP_001353140; NP_001353141; NP_001353142; NP_001353143; NP_001353144; NP_001353145; NP_001353146; NP_001353147; NP_001353148; NP_001353149; NP_001353150; NP_001353151
NP_001239362; NP_001239363; NP_001239364; NP_001239365; NP_031888;
	NP_001344210; NP_001344211
	Wikidata
View/Edit Human	View/Edit Mouse

Discs large homolog 1 (DLG1), also known as synapse-associated protein 97 or SAP97, is a scaffold protein that in humans is encoded by the SAP97 gene.

SAP97 is a mammalian MAGUK-family member protein that is similar to the Drosophila protein Dlg1 (the protein is alternatively referred to as hDlg1, and the human gene is DLG1). SAP97 is expressed throughout the body in epithelial cells. In the brain it is involved in the trafficking of ionotropic receptors from the endoplasmic reticulum to the plasma membrane, and may be involved in the trafficking AMPAR during synaptic plasticity.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.