DNA damage-inducible transcript 3

DDIT3
Identifiers
Aliases	DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153, DNA damage-inducible transcript 3, DNA damage inducible transcript 3, C/EBPzeta, AltDDIT3
External IDs	OMIM: 126337 MGI: 109247 HomoloGene: 3012 GeneCards: DDIT3
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,521,737 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,132,157 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; left lobe of thyroid gland; ; substantia nigra; ; gastric mucosa; ; hypothalamus; ; right lobe of thyroid gland; ; putamen; ; caudate nucleus; ; right lobe of liver; ; renal cortex;
	Top expressed in
	calvaria; ; motor neuron; ; supraoptic nucleus; ; islet of Langerhans; ; seminiferous tubule; ; ankle joint; ; superior frontal gyrus; ; right lung lobe; ; soleus muscle; ; olfactory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; cAMP response element binding protein binding; transcription corepressor activity; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; transcription cis-regulatory region binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; leucine zipper domain binding; protein binding; protein heterodimerization activity; protein homodimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; cytosol; late endosome; CHOP-C/EBP complex; nucleoplasm; transcription factor AP-1 complex; protein-DNA complex; CHOP-ATF4 complex; CHOP-ATF3 complex; nucleus;
Biological process	apoptotic process; release of sequestered calcium ion into cytosol; negative regulation of protein kinase B signaling; negative regulation of fat cell differentiation; negative regulation of myoblast differentiation; regulation of transcription, DNA-templated; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; negative regulation of DNA binding; mRNA transcription by RNA polymerase II; positive regulation of neuron death; negative regulation of transcription by RNA polymerase II; Wnt signaling pathway; cell redox homeostasis; response to endoplasmic reticulum stress; PERK-mediated unfolded protein response; ER overload response; cellular response to DNA damage stimulus; transcription, DNA-templated; positive regulation of transcription, DNA-templated; ATF6-mediated unfolded protein response; positive regulation of neuron apoptotic process; response to unfolded protein; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; positive regulation of interleukin-8 production; response to starvation; negative regulation of determination of dorsal identity; cell cycle; regulation of DNA-templated transcription in response to stress; negative regulation of transcription, DNA-templated; negative regulation of canonical Wnt signaling pathway; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; blood vessel maturation; negative regulation of CREB transcription factor activity; endoplasmic reticulum unfolded protein response; establishment of protein localization to mitochondrion; intrinsic apoptotic signaling pathway in response to nitrosative stress; negative regulation of DNA-binding transcription factor activity; positive regulation of DNA-binding transcription factor activity; protein complex oligomerization; negative regulation of cold-induced thermogenesis; regulation of autophagy; positive regulation of intrinsic apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1649
	13198
	ENSG00000175197
	ENSMUSG00000025408
	P35638
	P35639
NM_001195053; NM_001195054; NM_001195055; NM_001195056; NM_001195057;
	NM_004083
	NM_001290183; NM_007837
NP_001181982; NP_001181983; NP_001181984; NP_001181985; NP_001181986;
	NP_004074
	NP_001277112; NP_031863
	Wikidata
View/Edit Human	View/Edit Mouse

DNA damage-inducible transcript 3, also known as C/EBP homologous protein (CHOP), is a pro-apoptotic transcription factor that is encoded by the DDIT3 gene. It is a member of the CCAAT/enhancer-binding protein (C/EBP) family of DNA-binding transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis and has an important role in the cell's stress response.

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