Dopamine receptor D₄

DRD4
Identifiers
Aliases	DRD4, D4DR, dopamine receptor D4
External IDs	OMIM: 126452 MGI: 94926 HomoloGene: 20215 GeneCards: DRD4
Gene location (Human)
Chr.	Chromosome 11 (human)
End	640,706 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	140,876,377 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; pituitary gland; ; anterior pituitary; ; sural nerve; ; canal of the cervix; ; putamen; ; myometrium; ; skin of abdomen; ; right lobe of liver; ; hippocampus proper;
	Top expressed in
	retinal pigment epithelium; ; seminiferous tubule; ; iris; ; cumulus cell; ; ciliary body; ; condyle; ; meninges; ; axial skeleton; ; pineal gland; ; adrenal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; potassium channel regulator activity; SH3 domain binding; identical protein binding; dopamine neurotransmitter receptor activity; G protein-coupled receptor activity; protein binding; dopamine binding; dopamine neurotransmitter receptor activity, coupled via Gi/Go; epinephrine binding; norepinephrine binding; metal ion binding; G protein-coupled serotonin receptor activity; neurotransmitter receptor activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; postsynapse; glutamatergic synapse; dendrite;
Biological process	response to amphetamine; rhythmic process; arachidonic acid secretion; regulation of circadian rhythm; positive regulation of dopamine uptake involved in synaptic transmission; signal transduction; fear response; dopamine metabolic process; behavioral response to ethanol; behavioral response to cocaine; positive regulation of sodium:proton antiporter activity; cellular calcium ion homeostasis; positive regulation of kinase activity; adult locomotory behavior; inhibitory postsynaptic potential; negative regulation of protein secretion; social behavior; negative regulation of voltage-gated calcium channel activity; regulation of dopamine metabolic process; response to histamine; behavioral fear response; dopamine receptor signaling pathway; G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting dopamine receptor signaling pathway; regulation of postsynaptic neurotransmitter receptor internalization; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; chemical synaptic transmission; G protein-coupled serotonin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1815
	13491
	ENSG00000069696; ENSG00000276825
	ENSMUSG00000025496
	P21917
	P51436
	NM_000797
	NM_007878
	NP_000788
	NP_031904
	Wikidata
View/Edit Human	View/Edit Mouse

The dopamine receptor D₄ is a dopamine D2-like G protein-coupled receptor encoded by the DRD4 gene on chromosome 11 at 11p15.5.

The structure of DRD4 was recently reported in complex with the antipsychotic drug nemonapride.

As with other dopamine receptor subtypes, the D₄ receptor is activated by the neurotransmitter dopamine. It is linked to many neurological and psychiatric conditions including schizophrenia and bipolar disorder, ADHD, addictive behaviors, Parkinson's disease, and eating disorders such as anorexia nervosa. A weak association has been drawn between DRD4 and borderline personality disorder.

It is also a target for drugs which treat schizophrenia and Parkinson's disease. The D₄ receptor is considered to be D₂-like in which the activated receptor inhibits the enzyme adenylate cyclase, thereby reducing the intracellular concentration of the second messenger cyclic AMP.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

Dopamine receptor D4

Dopamine receptor D₄