Ganciclovir

Ganciclovir
Clinical data
Pronunciation	/ɡænˈsaɪkləvɪər/
Trade names	Cytovene; Cymevene; Vitrasert
Other names	gancyclovir; DHPG; 9-(1,3-dihydroxy-2-propoxymethyl)guanine
AHFS/Drugs.com	Monograph
MedlinePlus	a605011
License data	US DailyMed: Ganciclovir;
Pregnancy; category	AU: D;
Routes of; administration	Intravenous, by mouth, intravitreal
ATC code	J05AB06 (WHO) S01AD09 (WHO);
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: WARNINGRx-only;
Pharmacokinetic data
Bioavailability	5% (oral)
Metabolism	guanylate kinase (CMV UL97 gene product)
Elimination half-life	2.5–5 hours
Excretion	Kidney
Identifiers
	IUPAC name 2-Amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-one;
CAS Number	82410-32-0 ;
PubChem CID	3454;
DrugBank	DB01004 ;
ChemSpider	3336 ;
UNII	P9G3CKZ4P5;
KEGG	D00333 ;
ChEBI	CHEBI:465284 ;
ChEMBL	ChEMBL182 ;
CompTox Dashboard (EPA)	DTXSID8041032 ;
ECHA InfoCard	100.155.403
Chemical and physical data
Formula	C9H13N5O4
Molar mass	255.234 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	250 °C (482 °F) (dec.)
	SMILES O=C2/N=C(\Nc1n(cnc12)COC(CO)CO)N;
	InChI InChI=1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17) ; Key:IRSCQMHQWWYFCW-UHFFFAOYSA-N ;
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Ganciclovir, sold under the brand name Cytovene among others, is an antiviral medication used to treat cytomegalovirus (CMV) infections.

Ganciclovir was patented in 1980 and approved for medical use in 1988; it was discovered by Dr Hoong-Wei Gan.

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