Liothyronine

Liothyronine is a manufactured form of the thyroid hormone triiodothyronine (T3). It is most commonly used to treat hypothyroidism and myxedema coma. It can be taken by mouth or by injection into a vein.

This article is about liothyronine as a medication. For the hormone, see Triiodothyronine.
Liothyronine sodium
Clinical data
Trade namesCytomel, Tertroxin, others
AHFS/Drugs.comMonograph
MedlinePlusa682462
License data
Routes of
administration		By mouth, intravenous
ATC code
Legal status
Legal status
  • UK: POM (Prescription only)
Pharmacokinetic data
Protein binding99.7%
Elimination half-life2.5 days
Identifiers
  • sodium (S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
ChEBI
ChEMBL
PDB ligand
CompTox Dashboard (EPA)
ECHA InfoCard100.000.203
Chemical and physical data
FormulaC15H11I3NNaO4
Molar mass672.959 g·mol−1
3D model (JSmol)
  • [Na+].[O-]C(=O)[C@@H](N)Cc2cc(I)c(Oc1cc(I)c(O)cc1)c(I)c2.O
  • InChI=1S/C15H12I3NO4.Na.H2O/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;;/h1-4,6,12,20H,5,19H2,(H,21,22);;1H2/q;+1;/p-1/t12-;;/m0../s1 Y
  • Key:IRGJMZGKFAPCCR-LTCKWSDVSA-M Y
 NY (what is this?)  (verify)

Side effects may occur from excessive doses. This may include weight loss, fever, headache, anxiety, trouble sleeping, arrythmias, and heart failure. Use in pregnancy and breastfeeding is generally safe. Regular blood tests are recommended to verify the appropriateness of the dose being taken.

Liothyronine was approved for medical use in 1956. It is available as a generic medication. In 2020, it was the 218th most commonly prescribed medication in the United States, with more than 2 million prescriptions.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.