Cytochrome c oxidase subunit 2

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Cytochrome c oxidase subunit II, transmembrane domain
Cytochrome c oxidase subunit II, transmembrane domain
	Bacterial cytochrome c oxidase complex. Subunit II indicated by blue.
Identifiers
Symbol	COX2_TM
Pfam	PF02790
InterPro	IPR011759
PROSITE	PDOC00075
SCOP2	1occ / SCOPe / SUPFAM
TCDB	3.D.4
OPM superfamily	4
OPM protein	1v55
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

COX2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3VRJ
Identifiers
Aliases	COX2, mitochondrially encoded cytochrome c oxidase II, COII, MTCO2, Cytochrome c oxidase subunit II, CO II
External IDs	OMIM: 516040 MGI: 102503 HomoloGene: 5017 GeneCards: COX2
Gene location (Human)
Chr.	Mitochondrial DNA (human)
End	8,269 bp
Gene location (Mouse)
Chr.	Mitochondrial DNA (mouse)
End	7,696 bp
RNA expression pattern
	Top expressed in
	putamen; ; caudate nucleus; ; nucleus accumbens; ; hippocampus proper; ; substantia nigra; ; hypothalamus; ; gastric mucosa; ; dorsolateral prefrontal cortex; ; amygdala; ; left ventricle;
	Top expressed in
	esophagus; ; zone of skin; ; ovary; ; jejunum; ; proximal tubule; ; duodenum; ; ganglionic eminence; ; bone marrow; ; quadriceps femoris muscle; ; ileum;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; metal ion binding; copper ion binding; oxidoreductase activity; cytochrome-c oxidase activity;
Cellular component	respiratory chain complex IV; respirasome; integral component of membrane; mitochondrion; membrane; extracellular exosome; mitochondrial respiratory chain complex IV; mitochondrial inner membrane;
Biological process	electron transport chain; response to cold; lactation; proton transmembrane transport; mitochondrial electron transport, cytochrome c to oxygen; ATP synthesis coupled electron transport; positive regulation of hydrogen peroxide biosynthetic process; positive regulation of necrotic cell death; positive regulation of ATP biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	4513
	17709
	ENSG00000198712
	ENSMUSG00000064354
	P00403
	P00405
	n/a
	n/a
	n/a
	NP_904331
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome c oxidase II is a protein in eukaryotes that is encoded by the MT-CO2 gene. Cytochrome c oxidase subunit II, abbreviated COXII, COX2, COII, or MT-CO2, is the second subunit of cytochrome c oxidase. It is also one of the three mitochondrial DNA (mtDNA) encoded subunits (MT-CO1, MT-CO2, MT-CO3) of respiratory complex IV.

Cytochrome C oxidase subunit II, periplasmic domain

Identifiers

Symbol

COX2

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

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