Cromoglicic acid

Cromoglicic acid
Clinical data
AHFS/Drugs.com	International Drug Names
License data	US FDA: Cromolyn;
Pregnancy; category	AU: B1;
Routes of; administration	topical: oral, nasal spray, inhaled, eye drops
ATC code	A07EB01 (WHO) D11AH03 (WHO) R01AC01 (WHO) R03BC01 (WHO) S01GX01 (WHO);
Legal status
Legal status	AU: S2 (Pharmacy medicine); UK: inhaler POM; eye OTC; US: OTC nasal; eye, inhaler: Rx only;
Pharmacokinetic data
Bioavailability	1%
Elimination half-life	1.3 hours
Identifiers
	IUPAC name 5,5′-(2-hydroxypropane-1,3-diyl)bis(oxy)bis(4-oxo-4H-chromene-2-carboxylic acid);
CAS Number	16110-51-3 ;
PubChem CID	2882;
IUPHAR/BPS	7608;
DrugBank	DB01003 ;
ChemSpider	2779 ;
UNII	Y0TK0FS77W;
KEGG	D07753 ;
ChEBI	CHEBI:59773 ;
ChEMBL	ChEMBL74 ;
CompTox Dashboard (EPA)	DTXSID4022860 ;
ECHA InfoCard	100.036.602
Chemical and physical data
Formula	C23H16O11
Molar mass	468.370 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)C=4Oc3cccc(OCC(O)COc2cccc1O/C(=C\C(=O)c12)C(=O)O)c3C(=O)C=4;
	InChI InChI=1S/C23H16O11/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30) ; Key:IMZMKUWMOSJXDT-UHFFFAOYSA-N ;
	(what is this?) (verify)

Cromoglicic acid (INN)—also referred to as cromolyn (USAN), cromoglycate (former BAN), or cromoglicate—is traditionally described as a mast cell stabilizer, and is commonly marketed as the sodium salt sodium cromoglicate or cromolyn sodium. This drug prevents the release of inflammatory chemicals such as histamine from mast cells.

Cromoglicic acid has been the non-corticosteroid treatment of choice in the treatment of asthma, for which it has largely been replaced by leukotriene receptor antagonists because of their convenience (and perceived safety). Cromoglicic acid requires administration four times daily, and does not provide additive benefit in combination with inhaled corticosteroids.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.