Constitutive androstane receptor

NR1I3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XVP, 1XV9
Identifiers
Aliases	NR1I3, CAR, CAR1, MB67, nuclear receptor subfamily 1 group I member 3
External IDs	OMIM: 603881 MGI: 1346307 HomoloGene: 3759 GeneCards: NR1I3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	161,238,244 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	171,048,270 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; nucleus accumbens; ; kidney; ; caudate nucleus; ; gastrocnemius muscle; ; putamen; ; prefrontal cortex; ; ganglionic eminence; ; bone marrow cells; ; left ventricle;
	Top expressed in
	left lobe of liver; ; duodenum; ; gallbladder; ; entorhinal cortex; ; jejunum; ; urethra; ; male urethra; ; morula; ; lens; ; pharynx;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription coactivator activity; zinc ion binding; metal ion binding; steroid hormone receptor activity; nuclear receptor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription cis-regulatory region binding; transcription factor binding; nuclear receptor coactivator activity; signaling receptor activity;
Cellular component	cytoplasm; cytosol; nucleoplasm; cytoskeleton; nucleus; RNA polymerase II transcription regulator complex;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; transcription initiation from RNA polymerase II promoter; negative regulation of transcription, DNA-templated; signal transduction; positive regulation of transcription by RNA polymerase II; steroid hormone mediated signaling pathway; androgen receptor signaling pathway; intracellular receptor signaling pathway; multicellular organism development; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	9970
	12355
	ENSG00000143257
	ENSMUSG00000005677
	Q14994; Q6GZ81
	O35627
NM_001077469; NM_001077470; NM_001077471; NM_001077472; NM_001077473;
	NM_001077474; NM_001077475; NM_001077476; NM_001077477; NM_001077478; NM_001077479; NM_001077480; NM_001077481; NM_001077482; NM_005122
	NM_001243062; NM_001243063; NM_009803
NP_001070937; NP_001070938; NP_001070939; NP_001070940; NP_001070941;
	NP_001070942; NP_001070943; NP_001070944; NP_001070945; NP_001070946; NP_001070947; NP_001070948; NP_001070949; NP_001070950; NP_005113
	NP_001229991; NP_001229992; NP_033933
	Wikidata
View/Edit Human	View/Edit Mouse

The constitutive androstane receptor (CAR) also known as nuclear receptor subfamily 1, group I, member 3 is a protein that in humans is encoded by the NR1I3 gene. CAR is a member of the nuclear receptor superfamily and along with pregnane X receptor (PXR) functions as a sensor of endobiotic and xenobiotic substances. In response, expression of proteins responsible for the metabolism and excretion of these substances is upregulated. Hence, CAR and PXR play a major role in the detoxification of foreign substances such as drugs.

Androstenol and several isomers of androstanol, androstanes, are endogenous antagonists of the CAR, and despite acting as antagonists, were the basis for the naming of this receptor. More recently, dehydroepiandrosterone (DHEA), also an androstane, has been found to be an endogenous agonist of the CAR.

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