Colipase

CLPS
Identifiers
Aliases	CLPS, entrez:1208, colipase
External IDs	OMIM: 120105 MGI: 88421 HomoloGene: 1383 GeneCards: CLPS
Gene location (Human)
Chr.	Chromosome 6 (human)
End	35,797,344 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	28,779,740 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; islet of Langerhans; ; pancreatic epithelial cell; ; right coronary artery; ; right uterine tube; ; right lobe of liver; ; oocyte; ; canal of the cervix; ; body of stomach; ; right adrenal gland;
	Top expressed in
	stomach; ; islet of Langerhans; ; jejunum; ; duodenum; ; colon; ; ileum; ; esophagus; ; morula; ; quadriceps femoris muscle; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	enzyme activator activity;
Cellular component	extracellular region;
Biological process	lipid catabolic process; digestion; positive regulation of catalytic activity; lipid metabolism; response to food; response to bacterium; retinoid metabolic process; lipid digestion;
	Sources:Amigo / QuickGO
Orthologs
	1208
	109791
	ENSG00000137392
	ENSMUSG00000024225
	P04118
	Q9CQC2
	NM_001832; NM_001252597; NM_001252598
	NM_025469; NM_001317065
	NP_001239526; NP_001239527; NP_001823
	NP_001303994; NP_079745
	Wikidata
View/Edit Human	View/Edit Mouse

Colipase, abbreviated CLPS, is a protein co-enzyme required for optimal enzyme activity of pancreatic lipase. It is secreted by the pancreas in an inactive form, procolipase, which is activated in the intestinal lumen by trypsin. Its function is to prevent the inhibitory effect of bile salts on the lipase-catalyzed intraduodenal hydrolysis of dietary long-chain triglycerides.

In humans, the colipase protein is encoded by the CLPS gene.

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