Clofibric acid

Clofibric acid is a biologically active metabolite of the lipid-lowering drugs clofibrate, etofibrate and theofibrate with the molecular formula C10H11ClO3. It has been found in the environment following use of these drugs, for example in Swiss lakes and the North Sea.

Clofibric acid
Names
Preferred IUPAC name
2-(4-Chlorophenoxy)-2-methylpropanoic acid
Other names
Clofibrin
Chlorofibrinic acid
Chlorophenoxyisobutyric acid
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.011.751
KEGG
UNII
  • InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13) Y
    Key: TXCGAZHTZHNUAI-UHFFFAOYSA-N Y
  • InChI=1/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)
    Key: TXCGAZHTZHNUAI-UHFFFAOYAP
  • Clc1ccc(OC(C(=O)O)(C)C)cc1
Properties
C10H11ClO3
Molar mass 214.645 g/mol
Appearance White to yellow solid
Melting point 118 to 123 °C (244 to 253 °F; 391 to 396 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Some derivatives of clofibric acid are in a drug class called fibrates.

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