Glycoprotein hormones, alpha polypeptide

CGA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DZ7, 1E9J, 1FL7, 1HCN, 1HD4, 1HRP, 1QFW, 1XWD, 4AY9, 4MQW
Identifiers
Aliases	CGA, CG-ALPHA, FSHA, GPHA1, GPHa, HCG, LHA, TSHA, Chorionic gonadotropin alpha, glycoprotein hormones, alpha polypeptide, Alpha subunit of glycoprotein hormones, GPA1
External IDs	OMIM: 118850 MGI: 88390 HomoloGene: 587 GeneCards: CGA
Gene location (Human)
Chr.	Chromosome 6 (human)
End	87,095,106 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	34,907,370 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; placenta; ; amniotic fluid; ; islet of Langerhans; ; hair follicle; ; right coronary artery; ; kidney; ; thymus; ; gastrocnemius muscle; ; body of pancreas;
	Top expressed in
	pituitary gland; ; median eminence; ; anterior pituitary; ; pars tuberalis; ; arcuate nucleus; ; morula; ; outer nuclear layer; ; inner nuclear layer; ; blastocyst; ; spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; hormone activity; follicle-stimulating hormone activity;
Cellular component	Golgi lumen; extracellular region; extracellular space; follicle-stimulating hormone complex;
Biological process	cell-cell signaling; peptide hormone processing; positive regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; signal transduction; positive regulation of cell migration; regulation of transcription by RNA polymerase II; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; positive regulation of steroid biosynthetic process; thyroid hormone generation;
	Sources:Amigo / QuickGO
Orthologs
	1081
	12640
	ENSG00000135346
	ENSMUSG00000028298
	P01215
	P01216
	NM_001252383; NM_000735
	NM_009889
	NP_000726; NP_001239312
	NP_034019
	Wikidata
View/Edit Human	View/Edit Mouse

Glycoprotein hormones, alpha polypeptide is a protein that in humans is encoded by the CGA gene.

The gonadotropin hormones, human chorionic gonadotropin (hCG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH) are heterodimers consisting of alpha and beta subunits (also called chains) that are associated non-covalently. The alpha subunits of these four human glycoprotein hormones are identical; however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family.

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