Cholesteryl ester transfer protein

CETP
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4F2A, 2OBD, 4EWS
Identifiers
Aliases	CETP, BPIFF, HDLCQ10, cholesteryl ester transfer protein
External IDs	OMIM: 118470 HomoloGene: 47904 GeneCards: CETP
Gene location (Human)
Chr.	Chromosome 16 (human)
End	56,983,845 bp
RNA expression pattern
	Top expressed in
	lymph node; ; spleen; ; liver; ; right lobe of liver; ; monocyte; ; gallbladder; ; left lobe of thyroid gland; ; appendix; ; right lobe of thyroid gland; ; placenta;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	triglyceride binding; phosphatidylcholine binding; lipid transporter activity; phospholipid transporter activity; cholesterol binding; cholesterol transfer activity; lipid binding;
Cellular component	vesicle; extracellular region; high-density lipoprotein particle; extracellular exosome; extracellular space;
Biological process	steroid metabolic process; phospholipid homeostasis; lipid transport; lipid metabolism; phospholipid transport; cholesterol transport; cholesterol metabolic process; regulation of cholesterol efflux; lipid homeostasis; very-low-density lipoprotein particle remodeling; triglyceride transport; cholesterol homeostasis; phosphatidylcholine metabolic process; triglyceride metabolic process; negative regulation of macrophage derived foam cell differentiation; triglyceride homeostasis; reverse cholesterol transport; low-density lipoprotein particle remodeling; high-density lipoprotein particle remodeling; transport;
	Sources:Amigo / QuickGO
Orthologs
	1071
	n/a
	ENSG00000087237
	n/a
	P11597
	n/a
	NM_000078; NM_001286085
	n/a
	NP_000069; NP_001273014
	n/a
	Wikidata
View/Edit Human

Cholesteryl ester transfer protein (CETP), also called plasma lipid transfer protein, is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins. It collects triglycerides from very-low-density (VLDL) or Chylomicrons and exchanges them for cholesteryl esters from high-density lipoproteins (HDL), and vice versa. Most of the time, however, CETP does a heteroexchange, trading a triglyceride for a cholesteryl ester or a cholesteryl ester for a triglyceride.

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