Cholesterol 7 alpha-hydroxylase

CYP7A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DAX, 3SN5, 3V8D
Identifiers
Aliases	CYP7A1, CP7A, CYP7, CYPVII, cytochrome P450 family 7 subfamily A member 1
External IDs	OMIM: 118455 MGI: 106091 HomoloGene: 30987 GeneCards: CYP7A1
Gene location (Human)
Chr.	Chromosome 8 (human)
End	58,500,163 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	6,275,633 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; duodenum; ; subcutaneous adipose tissue; ; abdominal wall; ; spleen; ; gallbladder; ; mammary gland; ; tibial nerve; ; skin of limb; ; heart;
	Top expressed in
	liver; ; left lobe of liver; ; secondary oocyte; ; trachea; ; thoracic diaphragm; ; proximal tubule; ; adipose tissue; ; right lung; ; white adipose tissue; ; jejunum;
	More reference expression data
	n/a
Gene ontology
Molecular function	iron ion binding; metal ion binding; monooxygenase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity; cholesterol 7-alpha-monooxygenase activity;
Cellular component	organelle membrane; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane; endoplasmic reticulum;
Biological process	steroid metabolic process; lipid metabolism; cholesterol metabolic process; cholesterol catabolic process; cellular response to cholesterol; regulation of bile acid biosynthetic process; sterol metabolic process; cholesterol homeostasis; bile acid biosynthetic process; cellular response to glucose stimulus; regulation of lipid metabolic process; positive regulation of cholesterol biosynthetic process; negative regulation of fatty acid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	1581
	13122
	ENSG00000167910
	ENSMUSG00000028240
	P22680
	Q64505
	NM_000780
	NM_007824
	NP_000771
	NP_031850
	Wikidata
View/Edit Human	View/Edit Mouse

Cholesterol 7 alpha-hydroxylase also known as cholesterol 7-alpha-monooxygenase or cytochrome P450 7A1 (CYP7A1) is an enzyme that in humans is encoded by the CYP7A1 gene which has an important role in cholesterol metabolism. It is a cytochrome P450 enzyme, which belongs to the oxidoreductase class, and converts cholesterol to 7-alpha-hydroxycholesterol, the first and rate limiting step in bile acid synthesis.

The inhibition of cholesterol 7-alpha-hydroxylase (CYP7A1) represses bile acid biosynthesis.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.